Colchicine Tablets 0.5 Mg has 29 known drug interactions based on U.S. FDA drug labeling data. Of these, 15 are contraindicated combinations that should be avoided entirely. 2 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Atazanavir, Clarithromycin, Cyclosporine. Patients taking Colchicine Tablets 0.5 Mg should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 29
- Contraindicated
- 15
- Major
- 2
- Moderate
- 11
Contraindicated (15)
- Colchicine Tablets 0.5 Mg + Atazanavir— Strong CYP3A4 inhibitor causing significant increases in colchicine plasma levels.
- Colchicine Tablets 0.5 Mg + Clarithromycin— Strong CYP3A4 inhibitor causing significant increases in colchicine plasma levels.
- Colchicine Tablets 0.5 Mg + Cyclosporine— Strong P-glycoprotein inhibitor causing significant increase in colchicine plasma levels. Contraindicated.
- Colchicine Tablets 0.5 Mg + Darunavir— Strong CYP3A4 inhibitor causing significant increases in colchicine plasma levels.
- Colchicine Tablets 0.5 Mg + Indinavir— Strong CYP3A4 inhibitor causing significant increases in colchicine plasma levels.
- Colchicine Tablets 0.5 Mg + Itraconazole— Strong CYP3A4 inhibitor causing significant increases in colchicine plasma levels.
- Colchicine Tablets 0.5 Mg + Ketoconazole— Strong CYP3A4 inhibitor causing significant increases in colchicine plasma levels.
- Colchicine Tablets 0.5 Mg + Lopinavir And Ritonavir— Strong CYP3A4 inhibitor causing significant increases in colchicine plasma levels.
- Colchicine Tablets 0.5 Mg + Nefazodone— Strong CYP3A4 inhibitor causing significant increases in colchicine plasma levels.
- Colchicine Tablets 0.5 Mg + Nelfinavir— Strong CYP3A4 inhibitor causing significant increases in colchicine plasma levels.
- Colchicine Tablets 0.5 Mg + Ranolazine— Strong P-glycoprotein inhibitor causing significant increase in colchicine plasma levels. Contraindicated.
- Colchicine Tablets 0.5 Mg + Ritonavir— Strong CYP3A4 inhibitor causing significant increases in colchicine plasma levels.
- Colchicine Tablets 0.5 Mg + Saquinavir— Strong CYP3A4 inhibitor causing significant increases in colchicine plasma levels.
- Colchicine Tablets 0.5 Mg + Telithromycin— Strong CYP3A4 inhibitor causing significant increases in colchicine plasma levels.
- Colchicine Tablets 0.5 Mg + Tipranavir— Strong CYP3A4 inhibitor causing significant increases in colchicine plasma levels.
Major (2)
- Colchicine Tablets 0.5 Mg + Digoxin— P-glycoprotein substrate with reported rhabdomyolysis when coadministered with colchicine.
- Colchicine Tablets 0.5 Mg + Gemfibrozil— Lipid-lowering drug with potential for pharmacokinetic/pharmacodynamic interaction causing myopathy and rhabdomyolysis. …
Moderate (11)
- Colchicine Tablets 0.5 Mg + Amprenavir— Moderate CYP3A4 Inhibitors amprenavir aprepitant diltiazem erythromycin fluconazole, fosamprenavir (prodrug of amprenavi…
- Colchicine Tablets 0.5 Mg + Aprepitant— Moderate CYP3A4 inhibitor causing significant increase in colchicine plasma concentration. Monitor for toxicity signs.
- Colchicine Tablets 0.5 Mg + Diltiazem— Moderate CYP3A4 inhibitor causing significant increase in colchicine plasma concentration. Monitor for toxicity signs.
- Colchicine Tablets 0.5 Mg + Erythromycin— Moderate CYP3A4 Inhibitors amprenavir aprepitant diltiazem erythromycin fluconazole, fosamprenavir (prodrug of amprenavi…
- Colchicine Tablets 0.5 Mg + Ethinyl Estradiol— Component of oral contraceptives; can cause adverse events like diarrhea, nausea, abdominal pain when coadministered. Us…
- Colchicine Tablets 0.5 Mg + Fluconazole— Moderate CYP3A4 Inhibitors amprenavir aprepitant diltiazem erythromycin fluconazole, fosamprenavir (prodrug of amprenavi…
- Colchicine Tablets 0.5 Mg + Fosamprenavir— Moderate CYP3A4 Inhibitors amprenavir aprepitant diltiazem erythromycin fluconazole, fosamprenavir (prodrug of amprenavi…
- Colchicine Tablets 0.5 Mg + Grapefruit Juice— Grapefruit juice increases exposure to colchicine. Advise patients to avoid grapefruit juice when taking colchicine.
- Colchicine Tablets 0.5 Mg + Grapefruit Products— Grapefruit increases exposure to colchicine. Advise patients to avoid grapefruit when taking colchicine.
- Colchicine Tablets 0.5 Mg + Norethindrone— Component of oral contraceptives; can cause adverse events like diarrhea, nausea, abdominal pain when coadministered. Us…
- Colchicine Tablets 0.5 Mg + Verapamil— Moderate CYP3A4 inhibitor causing significant increase in colchicine plasma concentration. Monitor for toxicity signs.