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Acalabrutinib

Also known as: Calquence

Kinase InhibitorTyrosine Kinase Inhibitors

Route: Oral

5 interactions on record

Acalabrutinib has 5 known drug interactions based on U.S. FDA drug labeling data. 2 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Itraconazole, Rifampin, Antacids Containing Calcium. Patients taking Acalabrutinib should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.

Total: 5
Major: 2
Moderate: 3

Major (2)

Acalabrutinib + Itraconazole— Strong CYP3A inhibitor increases acalabrutinib plasma concentrations, potentially resulting in increased toxicity. Avoid…
Acalabrutinib + Rifampin— Strong CYP3A inducer decreases acalabrutinib plasma concentrations, reducing CALQUENCE activity. Avoid co-administration…

Moderate (3)

Acalabrutinib + Antacids Containing Calcium— Antacid may decrease acalabrutinib plasma concentrations. Separate dosing by at least 2 hours.
Acalabrutinib + Famotidine— H2-receptor antagonist may decrease acalabrutinib concentrations. Take acalabrutinib 2 hours before famotidine dosing.
Acalabrutinib + Ranitidine— H2-receptor antagonist may decrease acalabrutinib concentrations. Take acalabrutinib 2 hours before ranitidine dosing.

Acalabrutinib + Itraconazole⚠️Major

Strong CYP3A inhibitor increases acalabrutinib plasma concentrations, potentially resulting in increased toxicity. Avoid co-administration or interrupt acalabrutinib if short-term use needed.

Acalabrutinib + Rifampin⚠️Major

Strong CYP3A inducer decreases acalabrutinib plasma concentrations, reducing CALQUENCE activity. Avoid co-administration or increase acalabrutinib dose to 200 mg every 12 hours if unavoidable.

Acalabrutinib + Antacids Containing Calcium🟡Moderate

Antacid may decrease acalabrutinib plasma concentrations. Separate dosing by at least 2 hours.

Acalabrutinib + Famotidine🟡Moderate

H2-receptor antagonist may decrease acalabrutinib concentrations. Take acalabrutinib 2 hours before famotidine dosing.

Acalabrutinib + Ranitidine🟡Moderate

H2-receptor antagonist may decrease acalabrutinib concentrations. Take acalabrutinib 2 hours before ranitidine dosing.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.