Does Acalabrutinib Interact with Famotidine?
CDI records a moderate classification for Acalabrutinib and Famotidine. The stored summary is: H2-receptor antagonist may decrease acalabrutinib concentrations. Take acalabrutinib 2 hours before famotidine dosing. The mechanism involves gastric acid reduction affecting absorption. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Moderate
- Acalabrutinib Class
- Kinase Inhibitor
- Famotidine Class
- Histamine-2 Receptor Antagonist
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
Gastric acid reduction affecting absorption
What To Tell Your Doctor or Pharmacist
If you are taking Acalabrutinib and your doctor is considering prescribing Famotidine (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider