Macimorelin Acetate has 30 known drug interactions based on U.S. FDA drug labeling data. Of these, 9 are contraindicated combinations that should be avoided entirely. 13 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Amiodarone, Chlorpromazine, Haloperidol. Patients taking Macimorelin Acetate should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 30
- Contraindicated
- 9
- Major
- 13
- Moderate
- 8
Contraindicated (9)
- Macimorelin Acetate + Amiodarone— Co-administration may lead to torsade de pointes-type ventricular tachycardia due to QT prolongation. Avoid concomitant …
- Macimorelin Acetate + Chlorpromazine— Co-administration may lead to torsade de pointes-type ventricular tachycardia due to QT prolongation. Avoid concomitant …
- Macimorelin Acetate + Haloperidol— Co-administration may lead to torsade de pointes-type ventricular tachycardia due to QT prolongation. Avoid concomitant …
- Macimorelin Acetate + Moxifloxacin— Co-administration may lead to torsade de pointes-type ventricular tachycardia due to QT prolongation. Avoid concomitant …
- Macimorelin Acetate + Procainamide— Co-administration may lead to torsade de pointes-type ventricular tachycardia due to QT prolongation. Avoid concomitant …
- Macimorelin Acetate + Quinidine— Co-administration may lead to torsade de pointes-type ventricular tachycardia due to QT prolongation. Avoid concomitant …
- Macimorelin Acetate + Sotalol— Co-administration may lead to torsade de pointes-type ventricular tachycardia due to QT prolongation. Avoid concomitant …
- Macimorelin Acetate + Thioridazine— Co-administration may lead to torsade de pointes-type ventricular tachycardia due to QT prolongation. Avoid concomitant …
- Macimorelin Acetate + Ziprasidone— Co-administration may lead to torsade de pointes-type ventricular tachycardia due to QT prolongation. Avoid concomitant …
Major (13)
- Macimorelin Acetate + Armodafinil— Strong CYP3A4 inducer may reduce plasma macimorelin concentrations and lead to false positive test results. Discontinue …
- Macimorelin Acetate + Bosentan— Strong CYP3A4 inducer may reduce plasma macimorelin concentrations and lead to false positive test results. Discontinue …
- Macimorelin Acetate + Carbamazepine— Strong CYP3A4 inducer may reduce plasma macimorelin concentrations and lead to false positive test results. Discontinue …
- Macimorelin Acetate + Efavirenz— Strong CYP3A4 inducer may reduce plasma macimorelin concentrations and lead to false positive test results. Discontinue …
- Macimorelin Acetate + Enzalutamide— Strong CYP3A4 inducer may reduce plasma macimorelin concentrations and lead to false positive test results. Discontinue …
- Macimorelin Acetate + Etravirine— Strong CYP3A4 inducer may reduce plasma macimorelin concentrations and lead to false positive test results. Discontinue …
- Macimorelin Acetate + Mitotane— Strong CYP3A4 inducer may reduce plasma macimorelin concentrations and lead to false positive test results. Discontinue …
- Macimorelin Acetate + Modafinil— Strong CYP3A4 inducer may reduce plasma macimorelin concentrations and lead to false positive test results. Discontinue …
- Macimorelin Acetate + Phenytoin— Strong CYP3A4 inducer may reduce plasma macimorelin concentrations and lead to false positive test results. Discontinue …
- Macimorelin Acetate + Rifampin— Strong CYP3A4 inducer may reduce plasma macimorelin concentrations and lead to false positive test results. Discontinue …
- Macimorelin Acetate + Rufinamide— Strong CYP3A4 inducer may reduce plasma macimorelin concentrations and lead to false positive test results. Discontinue …
- Macimorelin Acetate + Somatostatin— Avoid concomitant use of MACRILEN with the following [see Dosage and Administration ( 2.2 )] : Drugs that directly affec…
- Macimorelin Acetate + St. John'S Wort— Strong CYP3A4 inducer may reduce plasma macimorelin concentrations and lead to false positive test results. Discontinue …
Moderate (8)
- Macimorelin Acetate + Acetylsalicylic Acid— Cyclooxygenase inhibitor may impact accuracy of MACRILEN diagnostic test by directly affecting pituitary growth hormone …
- Macimorelin Acetate + Atropine— Muscarinic antagonist may blunt growth hormone response to MACRILEN and impact diagnostic test accuracy. Avoid concomita…
- Macimorelin Acetate + Clonidine— May transiently elevate growth hormone concentrations and impact accuracy of MACRILEN diagnostic test. Avoid concomitant…
- Macimorelin Acetate + Indomethacin— Cyclooxygenase inhibitor may impact accuracy of MACRILEN diagnostic test by directly affecting pituitary growth hormone …
- Macimorelin Acetate + Insulin Human— May impact accuracy of MACRILEN diagnostic test by directly affecting pituitary growth hormone secretion and transiently…
- Macimorelin Acetate + Levodopa— May transiently elevate growth hormone concentrations and impact accuracy of MACRILEN diagnostic test. Avoid concomitant…
- Macimorelin Acetate + Propylthiouracil— Anti-thyroid medication may blunt growth hormone response to MACRILEN and impact diagnostic test accuracy. Avoid concomi…
- Macimorelin Acetate + Somatropin— May blunt growth hormone response to MACRILEN. Discontinue at least one week before administering MACRILEN diagnostic te…