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Apalutamide

Also known as: Erleada

Route: Oral

9 interactions on record

Apalutamide has 9 known drug interactions based on U.S. FDA drug labeling data. Of these, 7 are contraindicated combinations that should be avoided entirely. Notable interactions include combinations with Atazanavir, Atazanavir And Cobicistat, Atazanavir Sulfate. Patients taking Apalutamide should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.

Total: 9
Contraindicated: 7
Moderate: 2

Contraindicated (7)

Apalutamide + Atazanavir— apalutamide ↓ atazanavir Coadministration of REYATAZ (with or without ritonavir) and apalutamide is contraindicated due …
Apalutamide + Atazanavir And Cobicistat— Antineoplastics: apalutamide ↓ atazanavir ↓cobicistat Coadministration with apalutamide is contraindicated due to the po…
Apalutamide + Atazanavir Sulfate— Antineoplastics: irinotecan apalutamide ivosidenib encorafenib ↑ irinotecan ↓ atazanavir ↓ atazanavir ↑ ivosidenib ↓ ata…
Apalutamide + Lopinavir And Ritonavir— Anticancer Agents: abemaciclib, apalutamide, encorafenib, ibrutinib, ivosidenib, dasatinib, neratinib, nilotinib, veneto…
Apalutamide + Nirmatrelvir And Ritonavir— Anticancer drugs apalutamide, enzalutamide ↓ nirmatrelvir/ritonavir Co-administration contraindicated due to potential l…
Apalutamide + Ritonavir— Anticancer Agents: abemaciclib, apalutamide, dasatinib, encorafenib, ibrutinib, ivosidenib, neratinib, nilotinib, veneto…
Apalutamide + Ritonavir 100 Mg— Anticancer Agents: abemaciclib, apalutamide, dasatinib, encorafenib, ibrutinib, ivosidenib, neratinib, nilotinib, veneto…

Moderate (2)

Apalutamide + Anti-Platelet Agents— Apalutamide induces P-glycoprotein and decreases exposure of P-gp substrates, which may decrease their effectiveness. Co…
Apalutamide + Mao Inhibitors— Strong CYP2C8 inhibitors increase steady-state exposure of apalutamide active moieties. Dose reduction of apalutamide is…

Apalutamide + Atazanavir⛔Contraindicated

apalutamide ↓ atazanavir Coadministration of REYATAZ (with or without ritonavir) and apalutamide is contraindicated due to the potential for subsequent loss of virologic response and possible resistance to the class of protease inhibitors [see Contraindications (4) ] .

Apalutamide + Atazanavir And Cobicistat⛔Contraindicated

Antineoplastics: apalutamide ↓ atazanavir ↓cobicistat Coadministration with apalutamide is contraindicated due to the potential for substantial decrease in plasma concentrations of atazanavir and cobicistat, which may result in loss of virologic response of EVOTAZ and possible resistance to atazanavir or to other protease inhibitors. Mechanism: The mechanism of interaction is CYP3A4 induction by apalutamide.

Apalutamide + Atazanavir Sulfate⛔Contraindicated

Antineoplastics: irinotecan apalutamide ivosidenib encorafenib ↑ irinotecan ↓ atazanavir ↓ atazanavir ↑ ivosidenib ↓ atazanavir ↑ encorafenib Coadministration of atazanavir with irinotecan is contraindicated. Coadministration of atazanavir (with or without ritonavir) and apalutamide is contraindicated due to the potential for subsequent loss of virologic response and possible resistance to the class of protease inhibitors [see Contraindications (4)] .

Apalutamide + Lopinavir And Ritonavir⛔Contraindicated

Anticancer Agents: abemaciclib, apalutamide, encorafenib, ibrutinib, ivosidenib, dasatinib, neratinib, nilotinib, venetoclax, vinblastine, vincristine ↑ anticancer agents ↓lopinavir/ritonavir # Apalutamide is contraindicated due to potential for loss of virologic response and possible resistance to KALETRA or to the class of protease inhibitors [see Contraindications ( 4 )] . # refers to interaction with apalutamide.

Apalutamide + Nirmatrelvir And Ritonavir⛔Contraindicated

Anticancer drugs apalutamide, enzalutamide ↓ nirmatrelvir/ritonavir Co-administration contraindicated due to potential loss of virologic response and possible resistance [see Contraindications (4) ].

Apalutamide + Ritonavir⛔Contraindicated

Anticancer Agents: abemaciclib, apalutamide, dasatinib, encorafenib, ibrutinib, ivosidenib, neratinib, nilotinib, venetoclax, vinblastine, vincristine ↑ anticancer agents ↓ ritonavir # Apalutamide is contraindicated due to potential for loss of virologic response and possible resistance to ritonavir or to the class of protease inhibitors [see Contraindications (4) ] . # refers to interaction with apalutamide.

Apalutamide + Ritonavir 100 Mg⛔Contraindicated

Apalutamide + Anti-Platelet Agents🟡Moderate

Apalutamide induces P-glycoprotein and decreases exposure of P-gp substrates, which may decrease their effectiveness. Consider alternative agents or monitor for loss of activity.

Apalutamide + Mao Inhibitors🟡Moderate

Strong CYP2C8 inhibitors increase steady-state exposure of apalutamide active moieties. Dose reduction of apalutamide is recommended.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine, supplemented with a small number of well-established interactions from curated clinical references. For informational purposes only. Always consult your pharmacist or physician.