Atazanavir And Cobicistat + Apalutamide Interaction
Contraindicatedinteraction on record
Description
Antineoplastics: apalutamide ↓ atazanavir ↓cobicistat Coadministration with apalutamide is contraindicated due to the potential for substantial decrease in plasma concentrations of atazanavir and cobicistat, which may result in loss of virologic response of EVOTAZ and possible resistance to atazanavir or to other protease inhibitors. Mechanism: The mechanism of interaction is CYP3A4 induction by apalutamide.
Source: FDA drug label - atazanavir and cobicistat