Enalapril Maleate has 26 known drug interactions based on U.S. FDA drug labeling data. Of these, 1 are contraindicated combinations that should be avoided entirely. 15 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Aliskiren, Amiloride, Angiotensin Ii. Patients taking Enalapril Maleate should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 26
- Contraindicated
- 1
- Major
- 15
- Moderate
- 3
- Minor
- 7
Contraindicated (1)
- Enalapril Maleate + Aliskiren— Do not coadminister aliskiren with enalapril maleate in patients with diabetes. Avoid use in patients with renal impairm…
Major (15)
- Enalapril Maleate + Amiloride— Potassium-sparing diuretic may lead to significant increases in serum potassium when used with enalapril.
- Enalapril Maleate + Angiotensin Ii— Dual blockade of RAS associated with increased risks of hypotension, hyperkalemia, and changes in renal function includi…
- Enalapril Maleate + Diuretics— Diuretics augment antihypertensive effect and may cause excessive blood pressure reduction, especially if recently insti…
- Enalapril Maleate + Enalapril— Closely monitor blood pressure, renal function, and electrolytes in patients on enalapril maleate and other agents that …
- Enalapril Maleate + Indomethacin— NSAID that may result in deterioration of renal function and diminish antihypertensive effect of enalapril, especially i…
- Enalapril Maleate + Lithium— Lithium toxicity reported in patients receiving enalapril and lithium concomitantly. Monitor serum lithium levels freque…
- Enalapril Maleate + Magnesium Sulfate Heptahydrate— Potassium-containing salt substitutes may lead to significant increases in serum potassium when combined with enalapril.
- Enalapril Maleate + Mao Inhibitors— Increased risk for angioedema in patients taking concomitant neprilysin inhibitors with enalapril maleate.
- Enalapril Maleate + Nonsteroidal Anti-Inflammatory Drugs (Nsaids)— May result in deterioration of renal function, including possible acute renal failure, especially in elderly, volume-dep…
- Enalapril Maleate + Nsaids— Co-administration may result in deterioration of renal function, including possible acute renal failure, especially in e…
- Enalapril Maleate + Potassium Supplements— Potassium supplements may lead to significant increases in serum potassium when combined with enalapril.
- Enalapril Maleate + Sodium Aurothiomalate— Nitritoid reactions (facial flushing, nausea, vomiting, hypotension) have been reported rarely with injectable gold and …
- Enalapril Maleate + Spironolactone— Potassium-sparing diuretic may lead to significant increases in serum potassium when used with enalapril.
- Enalapril Maleate + Sulindac— NSAID that may result in deterioration of renal function and diminish antihypertensive effect of enalapril, especially i…
- Enalapril Maleate + Triamterene— Potassium-sparing diuretic may lead to significant increases in serum potassium when used with enalapril.
Moderate (3)
- Enalapril Maleate + Drospirenone And Estradiol— Co-administration with drospirenone/estradiol results in mean serum potassium increase of 0.22 mEq/L above placebo basel…
- Enalapril Maleate + Loop Diuretics— Enalapril attenuates potassium loss caused by thiazide diuretics; monitor serum potassium.
- Enalapril Maleate + Rapamycin— mTOR (Mammalian Target of Rapamycin) Inhibitors Patients receiving coadministration of ACE inhibitor and mTOR inhibitor …
Minor (7)
- Enalapril Maleate + Calcium Antagonists— Used concomitantly with enalapril maleate without evidence of clinically significant adverse interactions.
- Enalapril Maleate + Digoxin— Used concomitantly with enalapril maleate without evidence of clinically significant adverse interactions.
- Enalapril Maleate + Hydralazine— Used concomitantly with enalapril maleate without evidence of clinically significant adverse interactions.
- Enalapril Maleate + Methyldopa— Used concomitantly with enalapril maleate without evidence of clinically significant adverse interactions.
- Enalapril Maleate + Nitrates— Used concomitantly with enalapril maleate without evidence of clinically significant adverse interactions.
- Enalapril Maleate + Nonselective Beta-Adrenergic Antagonists— Used concomitantly with enalapril maleate without evidence of clinically significant adverse interactions.
- Enalapril Maleate + Prazosin— Used concomitantly with enalapril maleate without evidence of clinically significant adverse interactions.