Does Nonsteroidal Anti Inflammatory Drugs Nsaids Interact with Enalapril Maleate?
CDI records a major classification for Nonsteroidal Anti Inflammatory Drugs Nsaids and Enalapril Maleate. The stored summary is: May result in deterioration of renal function, including possible acute renal failure, especially in elderly, volume-depleted, or renally compromised patients. May diminish antihypertensive effect. The mechanism involves renal function impairment through inhibition of prostaglandin-mediated renal blood flow. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Major
- Management
- Close medical supervision required
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
Renal function impairment through inhibition of prostaglandin-mediated renal blood flow
What To Tell Your Doctor or Pharmacist
If you are taking Nonsteroidal Anti Inflammatory Drugs Nsaids and your doctor is considering prescribing Enalapril Maleate (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask how frequently you should be monitored while these are co-prescribed
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider