Nortriptyline Hydrochloride has 11 known drug interactions based on U.S. FDA drug labeling data. 9 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Chlorpropamide, Cimetidine, Flecainide. Patients taking Nortriptyline Hydrochloride should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 11
- Major
- 9
- Moderate
- 2
Major (9)
- Nortriptyline Hydrochloride + Chlorpropamide— A case of significant hypoglycemia has been reported in a type II diabetic patient on chlorpropamide after addition of n…
- Nortriptyline Hydrochloride + Cimetidine— Concurrent administration with tricyclic antidepressants can produce clinically significant increases in plasma concentr…
- Nortriptyline Hydrochloride + Flecainide— Type 1C antiarrhythmic that inhibits P450 2D6, potentially increasing nortriptyline plasma concentrations to toxic level…
- Nortriptyline Hydrochloride + Fluoxetine— Inhibits P450 2D6 and may increase nortriptyline plasma concentrations. At least 5 weeks must elapse after fluoxetine wi…
- Nortriptyline Hydrochloride + Paroxetine— SSRI that inhibits P450 2D6. Caution indicated in co-administration with nortriptyline; may require dose adjustment.
- Nortriptyline Hydrochloride + Phenothiazines— Substrates for P450 2D6 that inhibit the enzyme, potentially increasing nortriptyline plasma concentrations to toxic lev…
- Nortriptyline Hydrochloride + Propafenone— Type 1C antiarrhythmic that inhibits P450 2D6, potentially increasing nortriptyline plasma concentrations to toxic level…
- Nortriptyline Hydrochloride + Quinidine— Inhibits cytochrome P450 2D6, which may cause abrupt toxicity in patients stable on nortriptyline by increasing plasma c…
- Nortriptyline Hydrochloride + Sertraline— SSRI that inhibits P450 2D6. Caution indicated in co-administration with nortriptyline; may require dose adjustment.
Moderate (2)
- Nortriptyline Hydrochloride + Alcohol— The response to alcohol may be exaggerated in patients taking nortriptyline hydrochloride.
- Nortriptyline Hydrochloride + Reserpine— Administration with nortriptyline has been shown to produce a "stimulating" effect in some depressed patients. Close sup…