Does Nortriptyline Hydrochloride Interact with Paroxetine?
Nortriptyline Hydrochloride and Paroxetine have a major drug interaction according to U.S. FDA drug labeling data. SSRI that inhibits P450 2D6. Caution indicated in co-administration with nortriptyline; may require dose adjustment. The mechanism involves inhibition of cytochrome p450 2d6. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Major
- Management
- Close medical supervision required
- Data Source
- U.S. FDA via OpenFDA
How This Interaction Works
The interaction between Nortriptyline Hydrochloride and Paroxetine occurs because inhibition of cytochrome p450 2d6. Clinically, this means ssri that inhibits p450 2d6. caution indicated in co-administration with nortriptyline; may require dose adjustment. This is classified as a major interaction, meaning it could cause serious harm if not properly managed. Your healthcare provider may need to adjust dosages, substitute one medication, or increase monitoring frequency.
What To Tell Your Doctor or Pharmacist
If you are taking Nortriptyline Hydrochloride and your doctor is considering prescribing Paroxetine (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask how frequently you should be monitored while these are co-prescribed
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider