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Methylprednisolone Sodium Succinate

Also known as: Solu-Medrol

Route: Intramuscular, Intravenous

Check Methylprednisolone Sodium Succinate Interactions →

22 interactions on record

Methylprednisolone Sodium Succinate has 22 known drug interactions based on U.S. FDA drug labeling data. 6 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Amphotericin B, Amphotericin B Injection, Anticholinesterase Agents. Patients taking Methylprednisolone Sodium Succinate should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.

Total: 22
Major: 6
Moderate: 16

Major (6)

Methylprednisolone Sodium Succinate + Amphotericin B— Concomitant use with potassium-depleting agents can cause hypokalemia. Cases reported of cardiac enlargement and congest…
Methylprednisolone Sodium Succinate + Amphotericin B Injection— Concomitant use with corticosteroids can cause hypokalemia and has been associated with cardiac enlargement and congesti…
Methylprednisolone Sodium Succinate + Anticholinesterase Agents— Concomitant use with corticosteroids may produce severe weakness in patients with myasthenia gravis.
Methylprednisolone Sodium Succinate + Cyclosporine— Increased activity of both cyclosporine and corticosteroids may occur with concurrent use; convulsions have been reporte…
Methylprednisolone Sodium Succinate + Digitalis Glycosides— Patients on digitalis glycosides may be at increased risk of arrhythmias due to hypokalemia from corticosteroid use.
Methylprednisolone Sodium Succinate + Ketoconazole— Significantly decreases corticosteroid metabolism by up to 60%, leading to increased risk of corticosteroid side effects…

Moderate (16)

Methylprednisolone Sodium Succinate + Acetylsalicylic Acid— Concomitant use with corticosteroids increases risk of gastrointestinal side effects; use cautiously in hypoprothrombine…
Methylprednisolone Sodium Succinate + Acidifying Agents— Corticosteroids may increase blood glucose concentrations, requiring dosage adjustments of antidiabetic agents.
Methylprednisolone Sodium Succinate + Aminoglutethimide— Aminoglutethimide may lead to a loss of corticosteroid-induced adrenal suppression.
Methylprednisolone Sodium Succinate + Barbiturates— Hepatic enzyme inducers that enhance corticosteroid metabolism and may require increased corticosteroid dosage.
Methylprednisolone Sodium Succinate + Carbamazepine— Hepatic enzyme inducer that enhances corticosteroid metabolism and may require increased corticosteroid dosage.
Methylprednisolone Sodium Succinate + Cholestyramine Light— Cholestyramine may increase the clearance of corticosteroids, reducing their effectiveness.
Methylprednisolone Sodium Succinate + Erythromycin— Macrolide antibiotic that may cause a significant decrease in corticosteroid clearance, increasing corticosteroid levels…
Methylprednisolone Sodium Succinate + Estrogens— Estrogens may decrease the hepatic metabolism of certain corticosteroids, thereby increasing their effect.
Methylprednisolone Sodium Succinate + Isoniazid— Serum concentrations of isoniazid may be decreased when used with corticosteroids.
Methylprednisolone Sodium Succinate + Macrolide Antibiotics— Macrolide antibiotics cause a significant decrease in corticosteroid clearance.
Methylprednisolone Sodium Succinate + Nonsteroidal Anti-Inflammatory Drugs (Nsaids)— Concomitant use with NSAIDs increases risk of gastrointestinal side effects.
Methylprednisolone Sodium Succinate + Oral Contraceptives— May decrease hepatic metabolism of certain corticosteroids, thereby increasing their effect.
Methylprednisolone Sodium Succinate + Phenytoin— Hepatic enzyme inducer that enhances corticosteroid metabolism and may require increased corticosteroid dosage.
Methylprednisolone Sodium Succinate + Rifampin— Hepatic enzyme inducer that enhances corticosteroid metabolism and may require increased corticosteroid dosage.
Methylprednisolone Sodium Succinate + Troleandomycin— Macrolide antibiotic that may cause a significant decrease in corticosteroid clearance, increasing corticosteroid levels…
Methylprednisolone Sodium Succinate + Warfarin— Coadministration of corticosteroids and warfarin usually results in inhibition of response to warfarin; coagulation indi…

Methylprednisolone Sodium Succinate + Amphotericin B⚠️Major

Concomitant use with potassium-depleting agents can cause hypokalemia. Cases reported of cardiac enlargement and congestive heart failure with concurrent amphotericin B and hydrocortisone.

Methylprednisolone Sodium Succinate + Amphotericin B Injection⚠️Major

Concomitant use with corticosteroids can cause hypokalemia and has been associated with cardiac enlargement and congestive heart failure.

Methylprednisolone Sodium Succinate + Anticholinesterase Agents⚠️Major

Concomitant use with corticosteroids may produce severe weakness in patients with myasthenia gravis.

Methylprednisolone Sodium Succinate + Cyclosporine⚠️Major

Increased activity of both cyclosporine and corticosteroids may occur with concurrent use; convulsions have been reported.

Methylprednisolone Sodium Succinate + Digitalis Glycosides⚠️Major

Patients on digitalis glycosides may be at increased risk of arrhythmias due to hypokalemia from corticosteroid use.

Methylprednisolone Sodium Succinate + Ketoconazole⚠️Major

Significantly decreases corticosteroid metabolism by up to 60%, leading to increased risk of corticosteroid side effects.

Methylprednisolone Sodium Succinate + Acetylsalicylic Acid🟡Moderate

Concomitant use with corticosteroids increases risk of gastrointestinal side effects; use cautiously in hypoprothrombinemia.

Methylprednisolone Sodium Succinate + Acidifying Agents🟡Moderate

Corticosteroids may increase blood glucose concentrations, requiring dosage adjustments of antidiabetic agents.

Methylprednisolone Sodium Succinate + Aminoglutethimide🟡Moderate

Aminoglutethimide may lead to a loss of corticosteroid-induced adrenal suppression.

Methylprednisolone Sodium Succinate + Barbiturates🟡Moderate

Hepatic enzyme inducers that enhance corticosteroid metabolism and may require increased corticosteroid dosage.

Methylprednisolone Sodium Succinate + Carbamazepine🟡Moderate

Hepatic enzyme inducer that enhances corticosteroid metabolism and may require increased corticosteroid dosage.

Methylprednisolone Sodium Succinate + Cholestyramine Light🟡Moderate

Cholestyramine may increase the clearance of corticosteroids, reducing their effectiveness.

Methylprednisolone Sodium Succinate + Erythromycin🟡Moderate

Macrolide antibiotic that may cause a significant decrease in corticosteroid clearance, increasing corticosteroid levels.

Methylprednisolone Sodium Succinate + Estrogens🟡Moderate

Estrogens may decrease the hepatic metabolism of certain corticosteroids, thereby increasing their effect.

Methylprednisolone Sodium Succinate + Isoniazid🟡Moderate

Serum concentrations of isoniazid may be decreased when used with corticosteroids.

Methylprednisolone Sodium Succinate + Macrolide Antibiotics🟡Moderate

Macrolide antibiotics cause a significant decrease in corticosteroid clearance.

Methylprednisolone Sodium Succinate + Nonsteroidal Anti-Inflammatory Drugs (Nsaids)🟡Moderate

Concomitant use with NSAIDs increases risk of gastrointestinal side effects.

Methylprednisolone Sodium Succinate + Oral Contraceptives🟡Moderate

May decrease hepatic metabolism of certain corticosteroids, thereby increasing their effect.

Methylprednisolone Sodium Succinate + Phenytoin🟡Moderate

Hepatic enzyme inducer that enhances corticosteroid metabolism and may require increased corticosteroid dosage.

Methylprednisolone Sodium Succinate + Rifampin🟡Moderate

Hepatic enzyme inducer that enhances corticosteroid metabolism and may require increased corticosteroid dosage.

Methylprednisolone Sodium Succinate + Troleandomycin🟡Moderate

Macrolide antibiotic that may cause a significant decrease in corticosteroid clearance, increasing corticosteroid levels.

Methylprednisolone Sodium Succinate + Warfarin🟡Moderate

Coadministration of corticosteroids and warfarin usually results in inhibition of response to warfarin; coagulation indices should be monitored.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.