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Methylprednisolone Sodium Succinate

Also known as: Solu-Medrol

Route: Intramuscular, Intravenous

Check Methylprednisolone Sodium Succinate Interactions →

22 interactions on record

Methylprednisolone Sodium Succinate has 22 known drug interactions based on U.S. FDA drug labeling data. 6 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Amphotericin B, Amphotericin B Injection, Anticholinesterase Agents. Patients taking Methylprednisolone Sodium Succinate should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.

Total: 22
Major: 6
Moderate: 16

Major (6)

Methylprednisolone Sodium Succinate + Amphotericin B— Concomitant use with potassium-depleting agents can cause hypokalemia. Cases reported of cardiac enlargement and congest…
Methylprednisolone Sodium Succinate + Amphotericin B Injection— Concomitant use with corticosteroids can cause hypokalemia and has been associated with cardiac enlargement and congesti…
Methylprednisolone Sodium Succinate + Anticholinesterase Agents— Concomitant use with corticosteroids may produce severe weakness in patients with myasthenia gravis.
Methylprednisolone Sodium Succinate + Cyclosporine— Increased activity of both cyclosporine and corticosteroids may occur with concurrent use; convulsions have been reporte…
Methylprednisolone Sodium Succinate + Digitalis Glycosides— Patients on digitalis glycosides may be at increased risk of arrhythmias due to hypokalemia from corticosteroid use.
Methylprednisolone Sodium Succinate + Ketoconazole— Significantly decreases corticosteroid metabolism by up to 60%, leading to increased risk of corticosteroid side effects…

Moderate (16)

Methylprednisolone Sodium Succinate + Acidifying Agents— Corticosteroids may increase blood glucose concentrations, requiring dosage adjustments of antidiabetic agents.
Methylprednisolone Sodium Succinate + Aminoglutethimide— Aminoglutethimide may lead to a loss of corticosteroid-induced adrenal suppression.
Methylprednisolone Sodium Succinate + Aspirin— Concomitant use with corticosteroids increases risk of gastrointestinal side effects; use cautiously in hypoprothrombine…
Methylprednisolone Sodium Succinate + Barbiturates— Hepatic enzyme inducers that enhance corticosteroid metabolism and may require increased corticosteroid dosage.
Methylprednisolone Sodium Succinate + Carbamazepine— Hepatic enzyme inducer that enhances corticosteroid metabolism and may require increased corticosteroid dosage.
Methylprednisolone Sodium Succinate + Cholestyramine Light— Cholestyramine may increase the clearance of corticosteroids, reducing their effectiveness.
Methylprednisolone Sodium Succinate + Erythromycin— Macrolide antibiotic that may cause a significant decrease in corticosteroid clearance, increasing corticosteroid levels…
Methylprednisolone Sodium Succinate + Estrogens— Estrogens may decrease the hepatic metabolism of certain corticosteroids, thereby increasing their effect.
Methylprednisolone Sodium Succinate + Isoniazid— Serum concentrations of isoniazid may be decreased when used with corticosteroids.
Methylprednisolone Sodium Succinate + Macrolide Antibiotics— Macrolide antibiotics cause a significant decrease in corticosteroid clearance.
Methylprednisolone Sodium Succinate + Nonsteroidal Anti-Inflammatory Drugs (Nsaids)— Concomitant use with NSAIDs increases risk of gastrointestinal side effects.
Methylprednisolone Sodium Succinate + Oral Contraceptives— May decrease hepatic metabolism of certain corticosteroids, thereby increasing their effect.
Methylprednisolone Sodium Succinate + Phenytoin— Hepatic enzyme inducer that enhances corticosteroid metabolism and may require increased corticosteroid dosage.
Methylprednisolone Sodium Succinate + Rifampin— Hepatic enzyme inducer that enhances corticosteroid metabolism and may require increased corticosteroid dosage.
Methylprednisolone Sodium Succinate + Troleandomycin— Macrolide antibiotic that may cause a significant decrease in corticosteroid clearance, increasing corticosteroid levels…
Methylprednisolone Sodium Succinate + Warfarin— Coadministration of corticosteroids and warfarin usually results in inhibition of response to warfarin; coagulation indi…

Methylprednisolone Sodium Succinate + Amphotericin B⚠️Major

Concomitant use with potassium-depleting agents can cause hypokalemia. Cases reported of cardiac enlargement and congestive heart failure with concurrent amphotericin B and hydrocortisone.

Methylprednisolone Sodium Succinate + Amphotericin B Injection⚠️Major

Concomitant use with corticosteroids can cause hypokalemia and has been associated with cardiac enlargement and congestive heart failure.

Methylprednisolone Sodium Succinate + Anticholinesterase Agents⚠️Major

Concomitant use with corticosteroids may produce severe weakness in patients with myasthenia gravis.

Methylprednisolone Sodium Succinate + Cyclosporine⚠️Major

Increased activity of both cyclosporine and corticosteroids may occur with concurrent use; convulsions have been reported.

Methylprednisolone Sodium Succinate + Digitalis Glycosides⚠️Major

Patients on digitalis glycosides may be at increased risk of arrhythmias due to hypokalemia from corticosteroid use.

Methylprednisolone Sodium Succinate + Ketoconazole⚠️Major

Significantly decreases corticosteroid metabolism by up to 60%, leading to increased risk of corticosteroid side effects.

Methylprednisolone Sodium Succinate + Acidifying Agents🟡Moderate

Corticosteroids may increase blood glucose concentrations, requiring dosage adjustments of antidiabetic agents.

Methylprednisolone Sodium Succinate + Aminoglutethimide🟡Moderate

Aminoglutethimide may lead to a loss of corticosteroid-induced adrenal suppression.

Methylprednisolone Sodium Succinate + Aspirin🟡Moderate

Concomitant use with corticosteroids increases risk of gastrointestinal side effects; use cautiously in hypoprothrombinemia.

Methylprednisolone Sodium Succinate + Barbiturates🟡Moderate

Hepatic enzyme inducers that enhance corticosteroid metabolism and may require increased corticosteroid dosage.

Methylprednisolone Sodium Succinate + Carbamazepine🟡Moderate

Hepatic enzyme inducer that enhances corticosteroid metabolism and may require increased corticosteroid dosage.

Methylprednisolone Sodium Succinate + Cholestyramine Light🟡Moderate

Cholestyramine may increase the clearance of corticosteroids, reducing their effectiveness.

Methylprednisolone Sodium Succinate + Erythromycin🟡Moderate

Macrolide antibiotic that may cause a significant decrease in corticosteroid clearance, increasing corticosteroid levels.

Methylprednisolone Sodium Succinate + Estrogens🟡Moderate

Estrogens may decrease the hepatic metabolism of certain corticosteroids, thereby increasing their effect.

Methylprednisolone Sodium Succinate + Isoniazid🟡Moderate

Serum concentrations of isoniazid may be decreased when used with corticosteroids.

Methylprednisolone Sodium Succinate + Macrolide Antibiotics🟡Moderate

Macrolide antibiotics cause a significant decrease in corticosteroid clearance.

Methylprednisolone Sodium Succinate + Nonsteroidal Anti-Inflammatory Drugs (Nsaids)🟡Moderate

Concomitant use with NSAIDs increases risk of gastrointestinal side effects.

Methylprednisolone Sodium Succinate + Oral Contraceptives🟡Moderate

May decrease hepatic metabolism of certain corticosteroids, thereby increasing their effect.

Methylprednisolone Sodium Succinate + Phenytoin🟡Moderate

Hepatic enzyme inducer that enhances corticosteroid metabolism and may require increased corticosteroid dosage.

Methylprednisolone Sodium Succinate + Rifampin🟡Moderate

Hepatic enzyme inducer that enhances corticosteroid metabolism and may require increased corticosteroid dosage.

Methylprednisolone Sodium Succinate + Troleandomycin🟡Moderate

Macrolide antibiotic that may cause a significant decrease in corticosteroid clearance, increasing corticosteroid levels.

Methylprednisolone Sodium Succinate + Warfarin🟡Moderate

Coadministration of corticosteroids and warfarin usually results in inhibition of response to warfarin; coagulation indices should be monitored.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine, supplemented with a small number of well-established interactions from curated clinical references. For informational purposes only. Always consult your pharmacist or physician.