Does Methylprednisolone Sodium Succinate Interact with Rifampin?
CDI records a moderate classification for Methylprednisolone Sodium Succinate and Rifampin. The stored summary is: Hepatic enzyme inducer that enhances corticosteroid metabolism and may require increased corticosteroid dosage. The mechanism involves cyp3a4 enzyme induction. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Moderate
- Rifampin Class
- Rifamycin Antibacterial
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
CYP3A4 enzyme induction
What To Tell Your Doctor or Pharmacist
If you are taking Methylprednisolone Sodium Succinate and your doctor is considering prescribing Rifampin (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider