Osilodrostat has 8 known drug interactions based on U.S. FDA drug labeling data. 5 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Carbamazepine, Clarithromycin, Itraconazole. Patients taking Osilodrostat should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 8
- Major
- 5
- Moderate
- 3
Major (5)
- Osilodrostat + Carbamazepine— Strong CYP3A4/CYP2B6 inducer may decrease osilodrostat concentration and reduce efficacy. Dose increase may be needed; m…
- Osilodrostat + Clarithromycin— Strong CYP3A4 inhibitor may increase osilodrostat concentration and risk of adverse reactions. Dose reduction by half re…
- Osilodrostat + Itraconazole— Strong CYP3A4 inhibitor may increase osilodrostat concentration and risk of adverse reactions. Dose reduction by half re…
- Osilodrostat + Phenobarbital— Strong CYP3A4/CYP2B6 inducer may decrease osilodrostat concentration and reduce efficacy. Dose increase may be needed; m…
- Osilodrostat + Rifampin— Strong CYP3A4/CYP2B6 inducer may decrease osilodrostat concentration and reduce efficacy. Dose increase may be needed; m…
Moderate (3)
- Osilodrostat + Mephenytoin— CYP2C19 substrate with narrow therapeutic index. Use with caution as osilodrostat may affect S-mephenytoin metabolism.
- Osilodrostat + Theophylline— CYP1A2 substrate with narrow therapeutic index. Use with caution as osilodrostat may affect theophylline metabolism.
- Osilodrostat + Tizanidine— CYP1A2 substrate with narrow therapeutic index. Use with caution as osilodrostat may affect tizanidine metabolism.