Does Theophylline Interact with Osilodrostat?
CDI records a moderate classification for Theophylline and Osilodrostat. The stored summary is: CYP1A2 substrate with narrow therapeutic index. Use with caution as osilodrostat may affect theophylline metabolism. The mechanism involves cyp1a2 substrate interaction. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Moderate
- Theophylline Class
- Methylxanthine
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
CYP1A2 substrate interaction
What To Tell Your Doctor or Pharmacist
If you are taking Theophylline and your doctor is considering prescribing Osilodrostat (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider