Doxycycline Hyclate Interactions

Barbiturates, carbamazepine, and phenytoin decrease the half-life of doxycycline.

Source: FDA drug label - doxycycline hyclate

However, there has been evidence of oncogenic activity in rats in studies with the related antibacterial drugs, oxytetracycline (adrenal and pituitary tumors), and minocycline (thyroid tumors).

Source: FDA drug label - doxycycline hyclate

However, there has been evidence of oncogenic activity in rats in studies with the related antibacterial drugs, oxytetracycline (adrenal and pituitary tumors), and minocycline (thyroid tumors). Likewise, although mutagenicity studies of doxycycline have not been conducted, positive results in in vitro mammalian cell assays have been reported for related antibacterial drugs (tetracycline, oxytetracycline).

Source: FDA drug label - doxycycline hyclate

penicillin) class of antibiotics, it is not advisable to administer these antibiotics concomitantly.

Source: FDA drug label - doxycycline hyclate

Drug Interactions Because tetracyclines have been shown to depress plasma prothrombin activity, patients who are on anticoagulant therapy may require downward adjustment of their anticoagulant dosage. Since bacterial antibiotics, such as the tetracycline class of antibiotics, may interfere with the bactericidal action of members of the β-lactam (e.g. Absorption of tetracyclines is impaired by antacids containing aluminum, calcium, or magnesium, and iron-containing preparations, and by bismuth subsalicylate.

Source: FDA drug label - doxycycline hyclate