Doxycycline Hyclate has 23 known drug interactions based on U.S. FDA drug labeling data. Of these, 1 are contraindicated combinations that should be avoided entirely. 3 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Methoxyflurane, Doxycycline, Penicillin. Patients taking Doxycycline Hyclate should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 23
- Contraindicated
- 1
- Major
- 3
- Moderate
- 17
Contraindicated (1)
- Doxycycline Hyclate + Methoxyflurane— Concurrent use of tetracycline and methoxyflurane has been reported to result in fatal renal toxicity.
Major (3)
- Doxycycline Hyclate + Doxycycline— 7 DRUG INTERACTIONS • Patients who are on anticoagulant therapy may require downward adjustment of their anticoagulant d…
- Doxycycline Hyclate + Penicillin— Since bacteriostatic drugs may interfere with the bactericidal action of penicillin, it is advisable to avoid giving tet…
- Doxycycline Hyclate + Tetracycline— Drug Interactions Because tetracyclines have been shown to depress plasma prothrombin activity, patients who are on anti…
Moderate (17)
- Doxycycline Hyclate + Aluminum Hydroxide— Antacids containing aluminum impair absorption of tetracyclines.
- Doxycycline Hyclate + Antacids Containing Aluminum— Aluminum-containing antacids impair absorption of tetracyclines.
- Doxycycline Hyclate + Antacids Containing Calcium— Antacids containing calcium impair absorption of tetracyclines.
- Doxycycline Hyclate + Antacids Containing Calcium, Magnesium, Or Aluminum— These antacids impair absorption of tetracyclines.
- Doxycycline Hyclate + Antacids Containing Magnesium— Magnesium-containing antacids impair absorption of tetracyclines.
- Doxycycline Hyclate + Barbiturates— Barbiturates decrease the half-life of doxycycline.
- Doxycycline Hyclate + Bismuth Subsalicylate— Bismuth subsalicylate impairs absorption of tetracyclines.
- Doxycycline Hyclate + Calcium Antagonists— Calcium-containing antacids impair absorption of tetracyclines.
- Doxycycline Hyclate + Carbamazepine— Carbamazepine decreases the half-life of doxycycline.
- Doxycycline Hyclate + Iron Supplements— Iron-containing preparations impair absorption of tetracyclines.
- Doxycycline Hyclate + Iron-Containing Preparations— Iron-containing preparations impair absorption of tetracyclines.
- Doxycycline Hyclate + Magnesium Hydroxide— Antacids containing magnesium impair absorption of tetracyclines.
- Doxycycline Hyclate + Oral Anticoagulants— Tetracyclines depress plasma prothrombin activity; anticoagulant dosage may require downward adjustment.
- Doxycycline Hyclate + Oral Contraceptives— Concurrent use of tetracycline may render oral contraceptives less effective.
- Doxycycline Hyclate + Phenytoin— Phenytoin decreases the half-life of doxycycline.
- Doxycycline Hyclate + Rifampin— Rifampin shortens the half-life of doxycycline, thereby lowering doxycycline concentration in the body.
- Doxycycline Hyclate + Steroid Therapy— Tetracyclines depress plasma prothrombin activity; patients may require downward adjustment of anticoagulant dosage.