Does Doxycycline Hyclate Interact with Rifampin?
CDI records a moderate classification for Doxycycline Hyclate and Rifampin. The stored summary is: Rifampin shortens the half-life of doxycycline, thereby lowering doxycycline concentration in the body. The mechanism involves shortened half-life. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Moderate
- Doxycycline Hyclate Class
- Tetracycline-class Drug
- Rifampin Class
- Rifamycin Antibacterial
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
Shortened half-life
What To Tell Your Doctor or Pharmacist
If you are taking Doxycycline Hyclate and your doctor is considering prescribing Rifampin (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider