Tiagabine Hydrochloride has 10 known drug interactions based on U.S. FDA drug labeling data. Notable interactions include combinations with Carbamazepine, Phenobarbital, Phenytoin. Patients taking Tiagabine Hydrochloride should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 10
- Moderate
- 5
- Minor
- 4
Moderate (5)
- Tiagabine Hydrochloride + Carbamazepine— Carbamazepine increases tiagabine clearance by 60%, which may require dose adjustments to maintain therapeutic efficacy.
- Tiagabine Hydrochloride + Phenobarbital— Phenobarbital increases tiagabine clearance by 60%, which may require dose adjustments to maintain therapeutic efficacy.
- Tiagabine Hydrochloride + Phenytoin— Phenytoin increases tiagabine clearance by 60%, which may require dose adjustments to maintain therapeutic efficacy.
- Tiagabine Hydrochloride + Primidone— Primidone increases tiagabine clearance by 60%, which may require dose adjustments to maintain therapeutic efficacy.
- Tiagabine Hydrochloride + Valproate— Tiagabine causes slight decrease (about 10%) in steady-state valproate concentrations. Valproate significantly decreases…
Minor (4)
- Tiagabine Hydrochloride + Cimetidine— Co-administration of cimetidine had no effect on tiagabine pharmacokinetics.
- Tiagabine Hydrochloride + Digoxin— Concomitant administration of tiagabine did not affect the steady-state pharmacokinetics of digoxin.
- Tiagabine Hydrochloride + Theophylline— Tiagabine did not affect the pharmacokinetics of theophylline at steady state.
- Tiagabine Hydrochloride + Warfarin— No significant differences observed in steady-state pharmacokinetics of R-warfarin or S-warfarin with tiagabine. Prothro…