Does Tiagabine Hydrochloride Interact with Valproate?
CDI records a moderate classification for Tiagabine Hydrochloride and Valproate. The stored summary is: Tiagabine causes slight decrease (about 10%) in steady-state valproate concentrations. Valproate significantly decreases tiagabine binding in vitro, resulting in approximately 40% increase in free tiagabine concentration. The mechanism involves valproate decreases tiagabine protein binding. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
Evidence status
A current label comparison is not yet available for this record. The summary and severity are stored CDI information; they have not been independently validated on this page against the exact product label.
Confirm the medicine, formulation, route, and applicable warning with your pharmacist or prescriber. Independent clinical review has not been recorded.
Saved label reference on DailyMed. This identifier has not been checked here as support for the current claim.
- Stored CDI classification
- Moderate
- Management
- Confirm exact products with your pharmacist
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
Valproate decreases tiagabine protein binding
What To Tell Your Doctor or Pharmacist
If you are taking Tiagabine Hydrochloride and your doctor is considering prescribing Valproate (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider