Thiazides

Should not be administered concomitantly due to possibility of augmented phototoxicity as thiazides are known photosensitizers.

Concomitant administration of thiazides with calcitriol causes hypercalcemia due to reduction of calcium excretion in urine. Precaution required.

Some thiazides are urinary alkalinizing agents that increase amphetamine blood levels and potentiate action. Co-administration should be avoided.

Increased incidence of thrombocytopenia with purpura reported in elderly patients concurrently receiving thiazides.

Thiazides produce hyperglycemia and may lead to loss of blood glucose control in patients receiving Acarbose. Close observation for loss of glucose control is recommended.

Thiazides may increase the catabolism of cholecalciferol. Additional vitamin D supplementation should be considered.

Concomitant administration may cause hypercalcemia due to thiazide-induced reduction in urinary calcium excretion. More frequent serum calcium monitoring required.

Concomitant use may cause hypercalcemia; precaution should be taken when coadministration is necessary.

Diuretics that produce hyperglycemia and may lead to loss of glycemic control.

Some thiazides act as urinary alkalinizing agents, increasing amphetamine levels and potentiating effects.

Some thiazides act as urinary alkalinizing agents, decreasing urinary excretion and potentiating amphetamine effects.

Concomitant administration may potentiate the hyperglycemic and hyperuricemic effects of diazoxide.

NSAIDs can reduce natriuretic effect of thiazides. Monitor patient for signs of renal failure and assure diuretic efficacy.

Diflunisal can reduce the natriuretic effect of thiazides in some patients.

Diuretic that may produce hyperglycemia and lead to loss of glycemic control; monitor closely.

May produce hyperglycemia and lead to loss of glycemic control; close monitoring recommended.

Thiazides may produce hyperglycemia and lead to loss of control of glyburide. Patients should be closely observed for loss of control.

May reduce glucose-lowering effect of glimepiride, leading to worsening glycemic control.

Thiazide diuretics may produce hyperglycemia and lead to loss of glycemic control. Patient should be observed closely for loss of control when initiated or withdrawn.

Thiazide diuretics may produce hyperglycemia and lead to loss of blood glucose control. Patient should be closely observed for loss of blood glucose control.

Thiazide diuretics tend to produce hyperglycemia and may lead to loss of glycemic control.

Ibuprofen can reduce the natriuretic effect of thiazide diuretics. Patient should be observed for signs of renal failure and to assure diuretic efficacy.

Ibuprofen can reduce the natriuretic effect of thiazide diuretics. Monitor for signs of renal failure and diuretic efficacy during concomitant therapy.

NSAIDs can reduce the natriuretic effect of thiazides in some patients. Patients are at greater risk of renal failure secondary to decreased renal blood flow.

Ketorolac can reduce the natriuretic effect of thiazide diuretics. Close observation for signs of renal failure and diuretic efficacy is needed during concomitant therapy.

Thiazide diuretics may produce hyperglycemia and lead to loss of glycemic control. Close monitoring of glycemic control is recommended.

Mefenamic acid can reduce the natriuretic effect of thiazides. Patient should be observed for signs of renal failure and diuretic efficacy.

NSAIDs may reduce natriuretic effect; monitor closely for renal failure and ensure diuretic efficacy during concomitant use.

Diuretics that produce hyperglycemia and may lead to loss of glycemic control; monitor blood glucose.

Diuretics that produce hyperglycemia and may lead to loss of glycemic control during metformin therapy.

Diuretic that may produce hyperglycemia and lead to loss of glycemic control with metformin.

Nabumetone can reduce the natriuretic effect of thiazide diuretics. Patient should be observed for signs of renal failure and diuretic efficacy during concomitant therapy.

Naproxen can reduce the natriuretic effect of thiazide diuretics. Monitor closely for signs of renal failure.

May reduce blood-glucose-lowering effect of nateglinide and increase susceptibility to hyperglycemia. Dose increases and increased glucose monitoring may be required.

Salsalate can reduce the natriuretic effect of thiazides in some patients. Close observation for renal failure and diuretic efficacy is recommended.

Diuretic that produces hyperglycemia and may lead to loss of glycemic control. Monitor blood glucose closely.

Sulindac can reduce natriuretic effect of thiazides; patient should be observed for signs of renal failure and to assure diuretic efficacy.

NSAIDs can reduce the natriuretic effect of thiazides in some patients. Patient should be observed closely for signs of renal failure and to assure diuretic efficacy.