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Chlorothiazide

Also known as: Diuril

Thiazide Diuretic

Route: Oral

17 interactions on record

Chlorothiazide has 17 known drug interactions based on U.S. FDA drug labeling data. Of these, 1 are contraindicated combinations that should be avoided entirely. 4 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Lithium, Colestipol Hydrochloride, Corticosteroids. Patients taking Chlorothiazide should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.

Total: 17
Contraindicated: 1
Major: 4
Moderate: 10

Contraindicated (1)

Chlorothiazide + Lithium— Lithium should generally not be given with chlorothiazide diuretics, as diuretics reduce renal clearance of lithium and …

Major (4)

Chlorothiazide + Colestipol Hydrochloride— Absorption of chlorothiazide is markedly decreased even when administered one hour before colestipol hydrochloride.
Chlorothiazide + Corticosteroids— Intensified electrolyte depletion, particularly hypokalemia, may occur with concurrent use of corticosteroids and chloro…
Chlorothiazide + Fludrocortisone Acetate— Potassium-depleting diuretics cause enhanced hypokalemia. Monitor serum potassium levels and use potassium supplements i…
Chlorothiazide + Repository Corticotropin— Intensified electrolyte depletion, particularly hypokalemia, may occur with concurrent use of ACTH and chlorothiazide.

Moderate (10)

Chlorothiazide + Acidifying Agents— Dosage adjustment of oral antidiabetic drugs may be required when used concurrently with chlorothiazide.
Chlorothiazide + Alcohol— Potentiation of orthostatic hypotension may occur when alcohol is given concurrently with chlorothiazide.
Chlorothiazide + Barbiturates— Potentiation of orthostatic hypotension may occur when barbiturates are given concurrently with chlorothiazide.
Chlorothiazide + Cholestyramine Light— Cholestyramine may bind thiazide diuretics and reduce diuretic absorption from the gastrointestinal tract.
Chlorothiazide + Colestipol— Colestipol resin may bind thiazide diuretics and reduce diuretic absorption from the gastrointestinal tract.
Chlorothiazide + Insulin Human— Dosage adjustment of insulin may be required when used concurrently with chlorothiazide.
Chlorothiazide + Lisinopril And Hydrochlorothiazide Tablets— Monitor blood pressure, renal function, and electrolytes in patients on Lisinopril and Hydrochlorothiazide Tablets and o…
Chlorothiazide + Lithium Carbonate— Diuretic-induced sodium loss may reduce lithium clearance and increase serum lithium concentrations.
Chlorothiazide + Norepinephrine— Possible decreased response to norepinephrine may occur, but not sufficient to preclude its use with chlorothiazide.
Chlorothiazide + Tubocurarine— Possible increased responsiveness to tubocurarine may occur when used concurrently with chlorothiazide.

Chlorothiazide + Lithium⛔Contraindicated

Lithium should generally not be given with chlorothiazide diuretics, as diuretics reduce renal clearance of lithium and add high risk of lithium toxicity.

Chlorothiazide + Colestipol Hydrochloride⚠️Major

Absorption of chlorothiazide is markedly decreased even when administered one hour before colestipol hydrochloride.

Chlorothiazide + Corticosteroids⚠️Major

Intensified electrolyte depletion, particularly hypokalemia, may occur with concurrent use of corticosteroids and chlorothiazide.

Chlorothiazide + Fludrocortisone Acetate⚠️Major

Potassium-depleting diuretics cause enhanced hypokalemia. Monitor serum potassium levels and use potassium supplements if necessary.

Chlorothiazide + Repository Corticotropin⚠️Major

Intensified electrolyte depletion, particularly hypokalemia, may occur with concurrent use of ACTH and chlorothiazide.

Chlorothiazide + Acidifying Agents🟡Moderate

Dosage adjustment of oral antidiabetic drugs may be required when used concurrently with chlorothiazide.

Chlorothiazide + Alcohol🟡Moderate

Potentiation of orthostatic hypotension may occur when alcohol is given concurrently with chlorothiazide.

Chlorothiazide + Barbiturates🟡Moderate

Potentiation of orthostatic hypotension may occur when barbiturates are given concurrently with chlorothiazide.

Chlorothiazide + Cholestyramine Light🟡Moderate

Cholestyramine may bind thiazide diuretics and reduce diuretic absorption from the gastrointestinal tract.

Chlorothiazide + Colestipol🟡Moderate

Colestipol resin may bind thiazide diuretics and reduce diuretic absorption from the gastrointestinal tract.

Chlorothiazide + Insulin Human🟡Moderate

Dosage adjustment of insulin may be required when used concurrently with chlorothiazide.

Chlorothiazide + Lisinopril And Hydrochlorothiazide Tablets🟡Moderate

Monitor blood pressure, renal function, and electrolytes in patients on Lisinopril and Hydrochlorothiazide Tablets and other agents that affect the RAS. Do not coadminister aliskiren with Lisinopril and Hydrochlorothiazide Tablets in patients with diabetes. No meaningful clinically important pharmacokinetic interactions occurred when lisinopril was used concomitantly with propranolol, digoxin, or hydrochlorothiazide.

Chlorothiazide + Lithium Carbonate🟡Moderate

Diuretic-induced sodium loss may reduce lithium clearance and increase serum lithium concentrations.

Chlorothiazide + Norepinephrine🟡Moderate

Possible decreased response to norepinephrine may occur, but not sufficient to preclude its use with chlorothiazide.

Chlorothiazide + Tubocurarine🟡Moderate

Possible increased responsiveness to tubocurarine may occur when used concurrently with chlorothiazide.

Chlorothiazide + Chlorothiazide Sodiumℹ️Unknown

Refer to the package insert for lithium preparations before use of such preparations with chlorothiazide sodium. Therefore, when chlorothiazide sodium and non-steroidal anti-inflammatory agents are used concomitantly, the patient should be observed closely to determine if the desired effect of the diuretic is obtained.

Chlorothiazide + Tolterodine Tartrateℹ️Unknown

Diuretics Coadministration of tolterodine immediate release up to 8 mg (4 mg bid) for up to 12 weeks with diuretic agents, such as indapamide, hydrochlorothiazide, triamterene, bendroflumethiazide, chlorothiazide, methylchlorothiazide, or furosemide, did not cause any adverse electrocardiographic (ECG) effects.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine, supplemented with a small number of well-established interactions from curated clinical references. For informational purposes only. Always consult your pharmacist or physician.