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Does Chlorothiazide Interact with Chlorothiazide Sodium?

CDI records a unknown classification for Chlorothiazide and Chlorothiazide Sodium. The stored summary is: Refer to the package insert for lithium preparations before use of such preparations with chlorothiazide sodium. Therefore, when chlorothiazide sodium and non-steroidal anti-inflammatory agents are used concomitantly, the patient should be observed closely to determine if the desired effect of the diuretic is obtained. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.

Severity
Unknown
Chlorothiazide Class
Thiazide Diuretic
Management
Consult your pharmacist
Data Source
U.S. FDA via OpenFDA

What To Tell Your Doctor or Pharmacist

If you are taking Chlorothiazide and your doctor is considering prescribing Chlorothiazide Sodium (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Never stop or change either medication without first consulting your healthcare provider
💊 Chlorothiazide(Diuril)+💊 Chlorothiazide Sodium(Chlorothiazide Sodium)

Severity & Interaction Details

ℹ️
unknown
Interaction documented — severity unclassified
The CDI record includes an interaction but its severity has not been classified.
Severity scale
MinorContra
On record
Yes
Drug A class
Thiazide Diuretic
Drug B class
—
Source
FDA drug label - chlorothiazide sodium

What this means in plain English

Refer to the package insert for lithium preparations before use of such preparations with chlorothiazide sodium. Therefore, when chlorothiazide sodium and non-steroidal anti-inflammatory agents are used concomitantly, the patient should be observed closely to determine if the desired effect of the diuretic is obtained.

About Chlorothiazide and Chlorothiazide Sodium

Chlorothiazide is a Thiazide Diuretic. Chlorothiazide is also sold under the brand name Diuril.

Source and Limitations

This record was produced by automated extraction from drug-label information, including AI processing. The summary and mechanism are not verbatim FDA quotations. The drug profiles below may describe different formulations from the source label. Confirm the exact product and route with your pharmacist. This page does not establish independent clinical review.

📖 Source: FDA drug label - chlorothiazide sodium

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How this information is prepared: CDI uses automated extraction, including AI, to summarize drug labeling from openFDA and includes separately identified curated-reference records. RxNorm helps identify medications; it does not verify interaction claims. Extracted summaries and CDI severity classifications can contain errors and are not verbatim FDA statements or independent clinical review. Maintained by CheckDrugInteractions.com. See our methodology or report a correction at support@checkdruginteractions.com.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine, supplemented with a small number of well-established interactions from curated clinical references. For informational purposes only. Always consult your pharmacist or physician.

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