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Lonafarnib

Also known as: Zokinvy

Farnesyltransferase InhibitorFarnesyltransferase InhibitorsCytochrome P450 2C8 Inhibitors

Route: Oral

10 interactions on record

Lonafarnib has 10 known drug interactions based on U.S. FDA drug labeling data. Of these, 7 are contraindicated combinations that should be avoided entirely. 1 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Atorvastatin, Loperamide, Lovastatin. Patients taking Lonafarnib should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.

Total: 10
Contraindicated: 7
Major: 1
Moderate: 2

Contraindicated (7)

Lonafarnib + Atorvastatin— Prevention or Management HMG CoA reductase inhibitors (“Statins”) Coadministration of ZOKINVY with lovastatin, simvastat…
Lonafarnib + Loperamide— Loperamide Clinical Impact Lonafarnib is a weak inhibitor of P-gp and strong inhibitor of CYP3A. Coadministration of ZOK…
Lonafarnib + Lovastatin— Prevention or Management HMG CoA reductase inhibitors (“Statins”) Coadministration of ZOKINVY with lovastatin, simvastat…
Lonafarnib + Mao Inhibitors— Concomitant use with strong CYP3A inhibitors is contraindicated. May increase lonafarnib AUC and Cmax, increasing incide…
Lonafarnib + Midazolam— Coadministration of ZOKINVY with a CYP3A substrate increases the AUC and C max of the CYP3A substrate [see Clinical Phar…
Lonafarnib + Simvastatin— Prevention or Management HMG CoA reductase inhibitors (“Statins”) Coadministration of ZOKINVY with lovastatin, simvastat…
Lonafarnib + Strong Or Moderate Cyp3a Inducers— Concomitant use is contraindicated. Decreases lonafarnib Cmax and AUC, which may reduce efficacy.

Major (1)

Lonafarnib + Drugs That Prolong Qtc Interval— Avoid concomitant use. Lonafarnib causes QTc prolongation; combined use may result in greater QTc interval increase and …

Moderate (2)

Lonafarnib + Grapefruit Products— Avoid consumption of grapefruit or Seville oranges during lonafarnib therapy due to CYP3A inhibition.
Lonafarnib + Seville Oranges— Avoid consumption of grapefruit or Seville oranges during lonafarnib therapy due to CYP3A inhibition.

Lonafarnib + Atorvastatin⛔Contraindicated

Prevention or Management HMG CoA reductase inhibitors (“Statins”) Coadministration of ZOKINVY with lovastatin, simvastatin, or atorvastatin is contraindicated [see Contraindications ( 4 )] . As noted above, use with lovastatin, simvastatin, or atorvastatin, and midazolam is contraindicated [see Contraindications ( 4 )] ).

Lonafarnib + Loperamide⛔Contraindicated

Loperamide Clinical Impact Lonafarnib is a weak inhibitor of P-gp and strong inhibitor of CYP3A. Coadministration of ZOKINVY with loperamide increases the AUC and C max of loperamide [see Clinical Pharmacology ( 12.3 )] which may increase the risk of loperamide's adverse reactions. Prevention or Management Loperamide is contraindicated in patients less than 2 years of age.

Lonafarnib + Lovastatin⛔Contraindicated

Lonafarnib + Mao Inhibitors⛔Contraindicated

Concomitant use with strong CYP3A inhibitors is contraindicated. May increase lonafarnib AUC and Cmax, increasing incidence and severity of adverse reactions including QTc interval prolongation.

Lonafarnib + Midazolam⛔Contraindicated

Coadministration of ZOKINVY with a CYP3A substrate increases the AUC and C max of the CYP3A substrate [see Clinical Pharmacology ( 12.3 )] which may increase the risk of the CYP3A substrate's adverse reactions, including myopathy or rhabdomyolysis (with statins), or extreme sedation or respiratory depression (with midazolam). Midazolam Coadministration of ZOKINVY with midazolam is contraindicated [see Contraindications ( 4 )] . Temporarily discontinue ZOKINVY for 10-14 days before and 2 days after administration of midazolam [see Dosage and Administration ( 2.3 )] .

Lonafarnib + Simvastatin⛔Contraindicated

Lonafarnib + Strong Or Moderate Cyp3a Inducers⛔Contraindicated

Concomitant use is contraindicated. Decreases lonafarnib Cmax and AUC, which may reduce efficacy.

Lonafarnib + Drugs That Prolong Qtc Interval⚠️Major

Avoid concomitant use. Lonafarnib causes QTc prolongation; combined use may result in greater QTc interval increase and serious arrhythmias including Torsade de pointes and sudden death.

Lonafarnib + Grapefruit Products🟡Moderate

Avoid consumption of grapefruit or Seville oranges during lonafarnib therapy due to CYP3A inhibition.

Lonafarnib + Seville Oranges🟡Moderate

Avoid consumption of grapefruit or Seville oranges during lonafarnib therapy due to CYP3A inhibition.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine, supplemented with a small number of well-established interactions from curated clinical references. For informational purposes only. Always consult your pharmacist or physician.