Lonafarnib has 10 known drug interactions based on U.S. FDA drug labeling data. Of these, 7 are contraindicated combinations that should be avoided entirely. 1 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Atorvastatin, Loperamide, Lovastatin. Patients taking Lonafarnib should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 10
- Contraindicated
- 7
- Major
- 1
- Moderate
- 2
Contraindicated (7)
- Lonafarnib + Atorvastatin— Prevention or Management HMG CoA reductase inhibitors (“Statins”) Coadministration of ZOKINVY with lovastatin, simvastat…
- Lonafarnib + Loperamide— Loperamide Clinical Impact Lonafarnib is a weak inhibitor of P-gp and strong inhibitor of CYP3A. Coadministration of ZOK…
- Lonafarnib + Lovastatin— Prevention or Management HMG CoA reductase inhibitors (“Statins”) Coadministration of ZOKINVY with lovastatin, simvastat…
- Lonafarnib + Mao Inhibitors— Concomitant use with strong CYP3A inhibitors is contraindicated. May increase lonafarnib AUC and Cmax, increasing incide…
- Lonafarnib + Midazolam— Coadministration of ZOKINVY with a CYP3A substrate increases the AUC and C max of the CYP3A substrate [see Clinical Phar…
- Lonafarnib + Simvastatin— Prevention or Management HMG CoA reductase inhibitors (“Statins”) Coadministration of ZOKINVY with lovastatin, simvastat…
- Lonafarnib + Strong Or Moderate Cyp3a Inducers— Concomitant use is contraindicated. Decreases lonafarnib Cmax and AUC, which may reduce efficacy.
Major (1)
- Lonafarnib + Drugs That Prolong Qtc Interval— Avoid concomitant use. Lonafarnib causes QTc prolongation; combined use may result in greater QTc interval increase and …
Moderate (2)
- Lonafarnib + Grapefruit Products— Avoid consumption of grapefruit or Seville oranges during lonafarnib therapy due to CYP3A inhibition.
- Lonafarnib + Seville Oranges— Avoid consumption of grapefruit or Seville oranges during lonafarnib therapy due to CYP3A inhibition.