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Does Lonafarnib Interact with Mao Inhibitors?

Lonafarnib and Mao Inhibitors have a contraindicated drug interaction according to U.S. FDA drug labeling data. Concomitant use with strong CYP3A inhibitors is contraindicated. May increase lonafarnib AUC and Cmax, increasing incidence and severity of adverse reactions including QTc interval prolongation. The mechanism involves cyp3a inhibition increases lonafarnib exposure. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Contraindicated
Lonafarnib Class
Farnesyltransferase Inhibitor
Management
Do not take together
Data Source
U.S. FDA via OpenFDA

How This Interaction Works

The interaction between Lonafarnib and Mao Inhibitors occurs because cyp3a inhibition increases lonafarnib exposure. Clinically, this means concomitant use with strong cyp3a inhibitors is contraindicated. may increase lonafarnib auc and cmax, increasing incidence and severity of adverse reactions including qtc interval prolongation. Because of the severity of this interaction, these medications are contraindicated — meaning they should not be taken together under any circumstances. If you are currently taking both, contact your healthcare provider immediately to discuss alternatives.

What To Tell Your Doctor or Pharmacist

If you are taking Lonafarnib and your doctor is considering prescribing Mao Inhibitors (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask about alternative medications that do not interact with your current regimen
  • Ask how frequently you should be monitored while these are co-prescribed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Lonafarnib(Zokinvy)+💊 Mao Inhibitors

Severity & Interaction Details

⛔
contraindicated
Avoid this combination
FDA labeling lists this pair as contraindicated. The risk outweighs the benefit in nearly all cases.
Severity scale
MinorContra
On record
Yes
Drug A class
Farnesyltransferase Inhibitor
Drug B class
—
Source
NLP:lonafarnib

What this means in plain English

Concomitant use with strong CYP3A inhibitors is contraindicated. May increase lonafarnib AUC and Cmax, increasing incidence and severity of adverse reactions including QTc interval prolongation.

What the FDA label says

"CYP3A inhibition increases lonafarnib exposure"

📖 Source: NLP:lonafarnib

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Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.