Gabapentin has 33 known drug interactions based on U.S. FDA drug labeling data. Of these, 2 are contraindicated combinations that should be avoided entirely. 20 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Oxycodone And Acetaminophen, Oxycodone Hydrochloride And Acetaminophen, Buprenorphine. Patients taking Gabapentin should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 33
- Contraindicated
- 2
- Major
- 20
- Moderate
- 4
- Minor
- 7
Contraindicated (2)
- Gabapentin + Oxycodone And Acetaminophen— Gabapentinoid CNS depressant that increases risk of hypotension, respiratory depression, profound sedation, coma, and de…
- Gabapentin + Oxycodone Hydrochloride And Acetaminophen— Gabapentinoid CNS depressant increasing risk of respiratory depression, profound sedation, coma, and death. Reserve for …
Major (20)
- Gabapentin + Buprenorphine— Gabapentinoid CNS depressant increases risk of respiratory depression, profound sedation, coma, and death.
- Gabapentin + Buprenorphine And Naloxone— CNS depressant that increases risk of respiratory depression, profound sedation, coma, and death when used concomitantly…
- Gabapentin + Buprenorphine Hydrochloride— CNS depressant with additive effects; concomitant use increases risk of respiratory depression, profound sedation, coma,…
- Gabapentin + Buprenorphine Hydrochloride And Naloxone Hydrochloride Dihydrate— Gabapentinoid CNS depressant increases risk of respiratory depression, profound sedation, coma, and death when used conc…
- Gabapentin + Butorphanol Tartrate— Gabapentinoid CNS depressant effects increase risk of respiratory depression, profound sedation, coma, and death.
- Gabapentin + Hydrocodone— Coadministration causes respiratory depression and sedation, sometimes resulting in death. Gabapentin decreases hydrocod…
- Gabapentin + Hydrocodone Bitartrate And Acetaminophen— Gabapentinoid CNS depressant with additive pharmacologic effect increasing risk of respiratory depression, sedation, and…
- Gabapentin + Hydrocodone Bitartrate And Ibuprofen— Gabapentinoid with additive CNS depressant effects when used with hydrocodone bitartrate and ibuprofen.
- Gabapentin + Hydromorphone Hydrochloride— CNS depressant effects can increase risk of hypotension, respiratory depression, profound sedation, coma, and death.
- Gabapentin + Levorphanol Tartrate— Gabapentinoid additive CNS depressant effects increase risk of hypotension, respiratory depression, profound sedation, c…
- Gabapentin + Methadone Hydrochloride— CNS depressant; concomitant use increases risk of respiratory depression, profound sedation, coma, and death.
- Gabapentin + Morphine— Coadministration may cause respiratory depression and sedation, sometimes resulting in death. Patients should be observe…
- Gabapentin + Morphine Sulfate— CNS depressant that increases risk of respiratory depression, profound sedation, coma, and death when used concomitantly…
- Gabapentin + Nalbuphine Hydrochloride— Gabapentinoid CNS depressant with additive effects increasing risk of respiratory depression, profound sedation, coma, a…
- Gabapentin + Oxycodone— Coadministration may cause respiratory depression and sedation, sometimes resulting in death.
- Gabapentin + Oxymorphone Hydrochloride— CNS depressant with additive effect increasing risk of hypotension, respiratory depression, profound sedation, coma, and…
- Gabapentin + Pentazocine Hydrochloride And Naloxone Hydrochloride— Concomitant use can increase risk of hypotension, respiratory depression, profound sedation, coma, and death due to addi…
- Gabapentin + Remifentanil Hydrochloride— Gabapentinoid CNS depressant increases risk of hypotension, respiratory depression, profound sedation, coma, and death.
- Gabapentin + Sufentanil— Gabapentinoid CNS depressant that increases risk of hypotension, respiratory depression, profound sedation, coma, and de…
- Gabapentin + Tapentadol Hydrochloride— CNS depressant effect increases risk of respiratory depression, profound sedation, coma, and death.
Moderate (4)
- Gabapentin + Aluminum & Magnesium Hydroxides— Concomitant use of antacid containing magnesium and aluminum hydroxides reduces gabapentin mean bioavailability by about…
- Gabapentin + Aluminum Hydroxide— Antacid containing aluminum hydroxide and magnesium hydroxide reduced gabapentin immediate release bioavailability by ap…
- Gabapentin + Maalox— Antacid containing aluminum hydroxide and magnesium hydroxide reduces gabapentin bioavailability by approximately 20%. T…
- Gabapentin + Magnesium Hydroxide— Antacid containing aluminum hydroxide and magnesium hydroxide reduced gabapentin immediate release bioavailability by ap…
Minor (7)
- Gabapentin + Carbamazepine— Steady-state carbamazepine and carbamazepine 10,11 epoxide concentrations were not affected by concomitant gabapentin, a…
- Gabapentin + Lacosamide— Steady-state plasma concentrations of gabapentin were not affected by concomitant lacosamide at any dose in clinical stu…
- Gabapentin + Levetiracetam— Levetiracetam does not influence gabapentin plasma concentration and gabapentin does not influence levetiracetam pharmac…
- Gabapentin + Naproxen— Coadministration of naproxen and gabapentin increased gabapentin absorption by 12% to 15%. Gabapentin had no effect on n…
- Gabapentin + Phenobarbital— Steady-state pharmacokinetic parameters for phenobarbital and gabapentin were identical whether administered alone or to…
- Gabapentin + Phenytoin— Gabapentin had no effect on steady-state phenytoin plasma concentrations, and phenytoin had no effect on gabapentin phar…
- Gabapentin + Valproic Acid— Mean steady-state valproic acid concentrations were not different with concomitant gabapentin, and gabapentin pharmacoki…