Does Gabapentin Interact with Naproxen?
Gabapentin and Naproxen have a minor drug interaction according to U.S. FDA drug labeling data. Coadministration of naproxen and gabapentin increased gabapentin absorption by 12% to 15%. Gabapentin had no effect on naproxen pharmacokinetics. The mechanism involves increased gabapentin absorption. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Minor
- Naproxen Class
- Nonsteroidal Anti-inflammatory Drug
- Management
- Generally manageable
- Data Source
- U.S. FDA via OpenFDA
How This Interaction Works
The interaction between Gabapentin and Naproxen occurs because increased gabapentin absorption. Clinically, this means coadministration of naproxen and gabapentin increased gabapentin absorption by 12% to 15%. gabapentin had no effect on naproxen pharmacokinetics. This is classified as a minor interaction with generally low clinical significance, though your healthcare provider should still be informed that you are taking both medications.
What To Tell Your Doctor or Pharmacist
If you are taking Gabapentin and your doctor is considering prescribing Naproxen (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Never stop or change either medication without first consulting your healthcare provider