Prilocaine Hydrochloride has 31 known drug interactions based on U.S. FDA drug labeling data. 31 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Acetaminophen, Acetazolamide, Articaine. Patients taking Prilocaine Hydrochloride should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 31
- Major
- 31
Major (31)
- Prilocaine Hydrochloride + Acetaminophen— Increased risk of methemoglobinemia when used concurrently with prilocaine.
- Prilocaine Hydrochloride + Acetazolamide— Increased risk of methemoglobinemia when used concurrently with prilocaine.
- Prilocaine Hydrochloride + Articaine— Increased risk of methemoglobinemia when used concurrently with prilocaine.
- Prilocaine Hydrochloride + Benzocaine— Increased risk of methemoglobinemia when used concurrently with prilocaine.
- Prilocaine Hydrochloride + Bupivacaine— Increased risk of methemoglobinemia when used concurrently with prilocaine.
- Prilocaine Hydrochloride + Chloroquine— Increased risk of methemoglobinemia when used concurrently with prilocaine.
- Prilocaine Hydrochloride + Cyclophosphamide— Clinically Significant Drug Interactions Patients who are administered local anesthetics are at increased risk of develo…
- Prilocaine Hydrochloride + Dapsone— Increased risk of methemoglobinemia when used concurrently with prilocaine.
- Prilocaine Hydrochloride + Ergot-Type Oxytocic Drugs— Concurrent use with vasopressor drugs may cause severe, persistent hypertension or cerebrovascular accidents.
- Prilocaine Hydrochloride + Flutamide— Clinically Significant Drug Interactions Patients who are administered local anesthetics are at increased risk of develo…
- Prilocaine Hydrochloride + Hydroxyurea— Increased risk of methemoglobinemia when used concurrently with prilocaine.
- Prilocaine Hydrochloride + Ifosfamide— Clinically Significant Drug Interactions Patients who are administered local anesthetics are at increased risk of develo…
- Prilocaine Hydrochloride + Lidocaine— Increased risk of methemoglobinemia when used concurrently with prilocaine.
- Prilocaine Hydrochloride + Mepivacaine— Increased risk of methemoglobinemia when used concurrently with prilocaine.
- Prilocaine Hydrochloride + Metoclopramide— Clinically Significant Drug Interactions Patients who are administered local anesthetics are at increased risk of develo…
- Prilocaine Hydrochloride + Nitric Oxide— Increased risk of methemoglobinemia when used concurrently with prilocaine.
- Prilocaine Hydrochloride + Nitrofurantoin— Increased risk of methemoglobinemia when used concurrently with prilocaine.
- Prilocaine Hydrochloride + Nitroglycerin— Increased risk of methemoglobinemia when used concurrently with prilocaine.
- Prilocaine Hydrochloride + Nitroprusside— Increased risk of methemoglobinemia when used concurrently with prilocaine.
- Prilocaine Hydrochloride + Nitrous Oxide— Increased risk of methemoglobinemia when used concurrently with prilocaine.
- Prilocaine Hydrochloride + Para-Aminosalicylic Acid— Increased risk of methemoglobinemia when used concurrently with prilocaine.
- Prilocaine Hydrochloride + Phenobarbital— Increased risk of methemoglobinemia when used concurrently with prilocaine.
- Prilocaine Hydrochloride + Phenytoin— Increased risk of methemoglobinemia when used concurrently with prilocaine.
- Prilocaine Hydrochloride + Primaquine— Increased risk of methemoglobinemia when used concurrently with prilocaine.
- Prilocaine Hydrochloride + Procaine— Increased risk of methemoglobinemia when used concurrently with prilocaine.
- Prilocaine Hydrochloride + Quinine— Increased risk of methemoglobinemia when used concurrently with prilocaine.
- Prilocaine Hydrochloride + Rasburicase— Increased risk of methemoglobinemia when used concurrently with prilocaine.
- Prilocaine Hydrochloride + Ropivacaine— Increased risk of methemoglobinemia when used concurrently with prilocaine.
- Prilocaine Hydrochloride + Sulfasalazine— Increased risk of methemoglobinemia when used concurrently with prilocaine.
- Prilocaine Hydrochloride + Tetracaine— Increased risk of methemoglobinemia when used concurrently with prilocaine.
- Prilocaine Hydrochloride + Valproate Sodium— Increased risk of methemoglobinemia when used concurrently with prilocaine.