Does Prilocaine Hydrochloride Interact with Nitrofurantoin?
CDI records a major classification for Prilocaine Hydrochloride and Nitrofurantoin. The stored summary is: Increased risk of methemoglobinemia when used concurrently with prilocaine. The mechanism involves drug associated with methemoglobinemia development. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Major
- Nitrofurantoin Class
- Nitrofuran Antibacterial
- Management
- Close medical supervision required
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
Drug associated with methemoglobinemia development
What To Tell Your Doctor or Pharmacist
If you are taking Prilocaine Hydrochloride and your doctor is considering prescribing Nitrofurantoin (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask how frequently you should be monitored while these are co-prescribed
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider