Glycopyrrolate Oral Solution has 7 known drug interactions based on U.S. FDA drug labeling data. Of these, 1 are contraindicated combinations that should be avoided entirely. 2 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Potassium Chloride, Digoxin, Haloperidol. Patients taking Glycopyrrolate Oral Solution should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 7
- Contraindicated
- 1
- Major
- 2
- Moderate
- 4
Contraindicated (1)
- Glycopyrrolate Oral Solution + Potassium Chloride— Solid dosage forms of potassium chloride are contraindicated. Passage through GI tract may be arrested or delayed with g…
Major (2)
- Glycopyrrolate Oral Solution + Digoxin— Slow dissolution digoxin tablets may have increased serum levels and enhanced action when coadministered with glycopyrro…
- Glycopyrrolate Oral Solution + Haloperidol— Haloperidol serum levels may decrease when coadministered with glycopyrrolate, resulting in worsening schizophrenic symp…
Moderate (4)
- Glycopyrrolate Oral Solution + Amantadine— Anticholinergic effects of glycopyrrolate may be increased with concomitant amantadine administration. Consider decreasi…
- Glycopyrrolate Oral Solution + Atenolol— Atenolol bioavailability may be increased with glycopyrrolate coadministration. Reduction in atenolol dose may be needed…
- Glycopyrrolate Oral Solution + Levodopa— Levodopa's therapeutic effect may be reduced with glycopyrrolate administration. Consider increasing levodopa dose.
- Glycopyrrolate Oral Solution + Metformin— Metformin plasma levels may be elevated with glycopyrrolate coadministration, increasing pharmacologic and toxic effects…