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Does Glycopyrrolate Oral Solution Interact with Digoxin?

Glycopyrrolate Oral Solution and Digoxin have a major drug interaction according to U.S. FDA drug labeling data. Slow dissolution digoxin tablets may have increased serum levels and enhanced action when coadministered with glycopyrrolate. Monitor for increased action; consider alternative dosage forms. The mechanism involves reduced gi transit time increasing absorption. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Major
Digoxin Class
Cardiac Glycoside
Management
Close medical supervision required
Data Source
U.S. FDA via OpenFDA

How This Interaction Works

The interaction between Glycopyrrolate Oral Solution and Digoxin occurs because reduced gi transit time increasing absorption. Clinically, this means slow dissolution digoxin tablets may have increased serum levels and enhanced action when coadministered with glycopyrrolate. monitor for increased action; consider alternative dosage forms. This is classified as a major interaction, meaning it could cause serious harm if not properly managed. Your healthcare provider may need to adjust dosages, substitute one medication, or increase monitoring frequency.

What To Tell Your Doctor or Pharmacist

If you are taking Glycopyrrolate Oral Solution and your doctor is considering prescribing Digoxin (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask how frequently you should be monitored while these are co-prescribed
  • Ask whether any dosage adjustments are needed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Glycopyrrolate Oral Solution(Glycopyrrolate Oral Solution)+💊 Digoxin(Digoxin)

Severity & Interaction Details

⚠️
major
Use with caution — major interaction
Serious risk of clinically significant harm. Generally avoid; if used, monitor closely.
Severity scale
MinorContra
On record
Yes
Drug A class
—
Drug B class
Cardiac Glycoside
Source
NLP:glycopyrrolate oral solution

What this means in plain English

Slow dissolution digoxin tablets may have increased serum levels and enhanced action when coadministered with glycopyrrolate. Monitor for increased action; consider alternative dosage forms.

What the FDA label says

"Reduced GI transit time increasing absorption"

📖 Source: NLP:glycopyrrolate oral solution

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Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.