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Articaine Hydrochloride And Epinephrine Bitartrate

Also known as: Articadent

Route: Submucosal

Check Articaine Hydrochloride And Epinephrine Bitartrate Interactions →

34 interactions on record

Articaine Hydrochloride And Epinephrine Bitartrate has 34 known drug interactions based on U.S. FDA drug labeling data. 32 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Acetaminophen, Acetazolamide, Benzocaine. Patients taking Articaine Hydrochloride And Epinephrine Bitartrate should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.

Total: 34
Major: 32
Moderate: 2

Major (32)

Articaine Hydrochloride And Epinephrine Bitartrate + Acetaminophen— Increased risk of developing methemoglobinemia when concurrently exposed to this agent.
Articaine Hydrochloride And Epinephrine Bitartrate + Acetazolamide— Increased risk of developing methemoglobinemia when concurrently exposed to this antibiotic class.
Articaine Hydrochloride And Epinephrine Bitartrate + Benzocaine— Increased risk of developing methemoglobinemia when concurrently exposed to this local anesthetic.
Articaine Hydrochloride And Epinephrine Bitartrate + Bupivacaine— Increased risk of developing methemoglobinemia when concurrently exposed to this local anesthetic.
Articaine Hydrochloride And Epinephrine Bitartrate + Chloroquine— Increased risk of developing methemoglobinemia when concurrently exposed to this antimalarial.
Articaine Hydrochloride And Epinephrine Bitartrate + Cyclophosphamide— Patients who are administered local anesthetics are at increased risk of developing methemoglobinemia when concurrently …
Articaine Hydrochloride And Epinephrine Bitartrate + Dapsone— Increased risk of developing methemoglobinemia when concurrently exposed to this antibiotic.
Articaine Hydrochloride And Epinephrine Bitartrate + Flutamide— Patients who are administered local anesthetics are at increased risk of developing methemoglobinemia when concurrently …
Articaine Hydrochloride And Epinephrine Bitartrate + Hydroxyurea— Increased risk of developing methemoglobinemia when concurrently exposed to this antineoplastic agent.
Articaine Hydrochloride And Epinephrine Bitartrate + Ifosfamide— Patients who are administered local anesthetics are at increased risk of developing methemoglobinemia when concurrently …
Articaine Hydrochloride And Epinephrine Bitartrate + Lidocaine— Increased risk of developing methemoglobinemia when concurrently exposed to this local anesthetic.
Articaine Hydrochloride And Epinephrine Bitartrate + Mepivacaine— Increased risk of developing methemoglobinemia when concurrently exposed to this local anesthetic.
Articaine Hydrochloride And Epinephrine Bitartrate + Metoclopramide— Patients who are administered local anesthetics are at increased risk of developing methemoglobinemia when concurrently …
Articaine Hydrochloride And Epinephrine Bitartrate + Monoamine Oxidase Inhibitors (Maois)— May produce severe, prolonged hypertension when local anesthetic solutions containing epinephrine are administered to pa…
Articaine Hydrochloride And Epinephrine Bitartrate + Nitric Oxide— Increased risk of developing methemoglobinemia when concurrently exposed to this nitrate.
Articaine Hydrochloride And Epinephrine Bitartrate + Nitrofurantoin— Increased risk of developing methemoglobinemia when concurrently exposed to this antibiotic.
Articaine Hydrochloride And Epinephrine Bitartrate + Nitroglycerin— Increased risk of developing methemoglobinemia when concurrently exposed to this nitrate.
Articaine Hydrochloride And Epinephrine Bitartrate + Nitroprusside— Increased risk of developing methemoglobinemia when concurrently exposed to this nitrite.
Articaine Hydrochloride And Epinephrine Bitartrate + Nitrous Oxide— Increased risk of developing methemoglobinemia when concurrently exposed to this nitrous oxide.
Articaine Hydrochloride And Epinephrine Bitartrate + Nonselective Beta-Adrenergic Antagonists— May produce severe, prolonged hypertension when local anesthetic solutions containing epinephrine are administered to pa…
Articaine Hydrochloride And Epinephrine Bitartrate + Para-Aminosalicylic Acid— Increased risk of developing methemoglobinemia when concurrently exposed to this antibiotic.
Articaine Hydrochloride And Epinephrine Bitartrate + Phenobarbital— Increased risk of developing methemoglobinemia when concurrently exposed to this anticonvulsant.
Articaine Hydrochloride And Epinephrine Bitartrate + Phenytoin— Increased risk of developing methemoglobinemia when concurrently exposed to this anticonvulsant.
Articaine Hydrochloride And Epinephrine Bitartrate + Prilocaine— Increased risk of developing methemoglobinemia when concurrently exposed to this local anesthetic.
Articaine Hydrochloride And Epinephrine Bitartrate + Primaquine— Increased risk of developing methemoglobinemia when concurrently exposed to this antimalarial.
Articaine Hydrochloride And Epinephrine Bitartrate + Procaine— Increased risk of developing methemoglobinemia when concurrently exposed to this local anesthetic.
Articaine Hydrochloride And Epinephrine Bitartrate + Quinine— Increased risk of developing methemoglobinemia when concurrently exposed to this agent.
Articaine Hydrochloride And Epinephrine Bitartrate + Rasburicase— Increased risk of developing methemoglobinemia when concurrently exposed to this antineoplastic agent.
Articaine Hydrochloride And Epinephrine Bitartrate + Ropivacaine— Increased risk of developing methemoglobinemia when concurrently exposed to this local anesthetic.
Articaine Hydrochloride And Epinephrine Bitartrate + Sulfasalazine— Increased risk of developing methemoglobinemia when concurrently exposed to this agent.
Articaine Hydrochloride And Epinephrine Bitartrate + Tetracaine— Increased risk of developing methemoglobinemia when concurrently exposed to this local anesthetic.
Articaine Hydrochloride And Epinephrine Bitartrate + Valproate Sodium— Increased risk of developing methemoglobinemia when concurrently exposed to this anticonvulsant.

Moderate (2)

Articaine Hydrochloride And Epinephrine Bitartrate + Butyrophenones— May reduce or reverse the pressor effect of epinephrine; concurrent use should generally be avoided but if necessary req…
Articaine Hydrochloride And Epinephrine Bitartrate + Phenothiazines— May reduce or reverse the pressor effect of epinephrine; concurrent use should generally be avoided but if necessary req…

Articaine Hydrochloride And Epinephrine Bitartrate + Acetaminophen⚠️Major

Increased risk of developing methemoglobinemia when concurrently exposed to this agent.

Articaine Hydrochloride And Epinephrine Bitartrate + Acetazolamide⚠️Major

Increased risk of developing methemoglobinemia when concurrently exposed to this antibiotic class.

Articaine Hydrochloride And Epinephrine Bitartrate + Benzocaine⚠️Major

Increased risk of developing methemoglobinemia when concurrently exposed to this local anesthetic.

Articaine Hydrochloride And Epinephrine Bitartrate + Bupivacaine⚠️Major

Increased risk of developing methemoglobinemia when concurrently exposed to this local anesthetic.

Articaine Hydrochloride And Epinephrine Bitartrate + Chloroquine⚠️Major

Increased risk of developing methemoglobinemia when concurrently exposed to this antimalarial.

Articaine Hydrochloride And Epinephrine Bitartrate + Cyclophosphamide⚠️Major

Patients who are administered local anesthetics are at increased risk of developing methemoglobinemia when concurrently exposed to the following drugs, which could include other local anesthetics: Table 5: Examples of Drugs Associated with Methemoglobinemia: Class Examples Nitrates/Nitrites nitric oxide, nitroglycerin, nitroprusside, nitrous oxide Local anesthetics articaine, benzocaine, bupivacaine, lidocaine, mepivacaine, prilocaine, ropivacaine, procaine, tetracaine Antineoplastic agents cyclophosphamide, flutamide, hydroxyurea, ifosfamide, rasburicase Antibiotics dapsone, nitrofurantoin, para-aminosalicylic acid, sulfonamides Antimalarials chloroquine, primaquine Anticonvulsants phenobarbital, phenytoin, sodium valproate, Other drugs acetaminophen, metoclopramide, quinine, sulfasalazine Monoamine Oxidase Inhibitors, Nonselective Beta-adrenergic Antagonists, or Tricyclic Antidepressants : May produce severe, prolonged hypertension ( 7 ) Phenothiazines and butyrophenones : May reduce or reverse the pressor effect of epinephrine ( 7 )

Articaine Hydrochloride And Epinephrine Bitartrate + Dapsone⚠️Major

Increased risk of developing methemoglobinemia when concurrently exposed to this antibiotic.

Articaine Hydrochloride And Epinephrine Bitartrate + Flutamide⚠️Major

Articaine Hydrochloride And Epinephrine Bitartrate + Hydroxyurea⚠️Major

Increased risk of developing methemoglobinemia when concurrently exposed to this antineoplastic agent.

Articaine Hydrochloride And Epinephrine Bitartrate + Ifosfamide⚠️Major

Articaine Hydrochloride And Epinephrine Bitartrate + Lidocaine⚠️Major

Increased risk of developing methemoglobinemia when concurrently exposed to this local anesthetic.

Articaine Hydrochloride And Epinephrine Bitartrate + Mepivacaine⚠️Major

Increased risk of developing methemoglobinemia when concurrently exposed to this local anesthetic.

Articaine Hydrochloride And Epinephrine Bitartrate + Metoclopramide⚠️Major

Articaine Hydrochloride And Epinephrine Bitartrate + Monoamine Oxidase Inhibitors (Maois)⚠️Major

May produce severe, prolonged hypertension when local anesthetic solutions containing epinephrine are administered to patients receiving MAOIs.

Articaine Hydrochloride And Epinephrine Bitartrate + Nitric Oxide⚠️Major

Increased risk of developing methemoglobinemia when concurrently exposed to this nitrate.

Articaine Hydrochloride And Epinephrine Bitartrate + Nitrofurantoin⚠️Major

Increased risk of developing methemoglobinemia when concurrently exposed to this antibiotic.

Articaine Hydrochloride And Epinephrine Bitartrate + Nitroglycerin⚠️Major

Increased risk of developing methemoglobinemia when concurrently exposed to this nitrate.

Articaine Hydrochloride And Epinephrine Bitartrate + Nitroprusside⚠️Major

Increased risk of developing methemoglobinemia when concurrently exposed to this nitrite.

Articaine Hydrochloride And Epinephrine Bitartrate + Nitrous Oxide⚠️Major

Increased risk of developing methemoglobinemia when concurrently exposed to this nitrous oxide.

Articaine Hydrochloride And Epinephrine Bitartrate + Nonselective Beta-Adrenergic Antagonists⚠️Major

May produce severe, prolonged hypertension when local anesthetic solutions containing epinephrine are administered to patients receiving these agents.

Articaine Hydrochloride And Epinephrine Bitartrate + Para-Aminosalicylic Acid⚠️Major

Increased risk of developing methemoglobinemia when concurrently exposed to this antibiotic.

Articaine Hydrochloride And Epinephrine Bitartrate + Phenobarbital⚠️Major

Increased risk of developing methemoglobinemia when concurrently exposed to this anticonvulsant.

Articaine Hydrochloride And Epinephrine Bitartrate + Phenytoin⚠️Major

Increased risk of developing methemoglobinemia when concurrently exposed to this anticonvulsant.

Articaine Hydrochloride And Epinephrine Bitartrate + Prilocaine⚠️Major

Increased risk of developing methemoglobinemia when concurrently exposed to this local anesthetic.

Articaine Hydrochloride And Epinephrine Bitartrate + Primaquine⚠️Major

Increased risk of developing methemoglobinemia when concurrently exposed to this antimalarial.

Articaine Hydrochloride And Epinephrine Bitartrate + Procaine⚠️Major

Increased risk of developing methemoglobinemia when concurrently exposed to this local anesthetic.

Articaine Hydrochloride And Epinephrine Bitartrate + Quinine⚠️Major

Increased risk of developing methemoglobinemia when concurrently exposed to this agent.

Articaine Hydrochloride And Epinephrine Bitartrate + Rasburicase⚠️Major

Increased risk of developing methemoglobinemia when concurrently exposed to this antineoplastic agent.

Articaine Hydrochloride And Epinephrine Bitartrate + Ropivacaine⚠️Major

Increased risk of developing methemoglobinemia when concurrently exposed to this local anesthetic.

Articaine Hydrochloride And Epinephrine Bitartrate + Sulfasalazine⚠️Major

Increased risk of developing methemoglobinemia when concurrently exposed to this agent.

Articaine Hydrochloride And Epinephrine Bitartrate + Tetracaine⚠️Major

Increased risk of developing methemoglobinemia when concurrently exposed to this local anesthetic.

Articaine Hydrochloride And Epinephrine Bitartrate + Valproate Sodium⚠️Major

Increased risk of developing methemoglobinemia when concurrently exposed to this anticonvulsant.

Articaine Hydrochloride And Epinephrine Bitartrate + Butyrophenones🟡Moderate

May reduce or reverse the pressor effect of epinephrine; concurrent use should generally be avoided but if necessary requires careful patient monitoring.

Articaine Hydrochloride And Epinephrine Bitartrate + Phenothiazines🟡Moderate

May reduce or reverse the pressor effect of epinephrine; concurrent use should generally be avoided but if necessary requires careful patient monitoring.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.