Promethazine Hydrochloride And Dextromethorphan Hydrobromide has 10 known drug interactions based on U.S. FDA drug labeling data. Of these, 3 are contraindicated combinations that should be avoided entirely. 6 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Epinephrine, Mao Inhibitors, Monoamine Oxidase Inhibitors (Maois). Patients taking Promethazine Hydrochloride And Dextromethorphan Hydrobromide should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 10
- Contraindicated
- 3
- Major
- 6
Contraindicated (3)
- Promethazine Hydrochloride And Dextromethorphan Hydrobromide + Epinephrine— Epinephrine should NOT be used to treat hypotension associated with overdose due to promethazine's potential to reverse …
- Promethazine Hydrochloride And Dextromethorphan Hydrobromide + Mao Inhibitors— Hyperpyrexia, hypotension, and death have been reported with coadministration of MAO inhibitors and dextromethorphan. Co…
- Promethazine Hydrochloride And Dextromethorphan Hydrobromide + Monoamine Oxidase Inhibitors (Maois)— Hyperpyrexia, hypotension, and death reported with co-administration. Increased extrapyramidal effects when MAO inhibito…
Major (6)
- Promethazine Hydrochloride And Dextromethorphan Hydrobromide + Alcohol— Promethazine may increase, prolong, or intensify sedative action of alcohol.
- Promethazine Hydrochloride And Dextromethorphan Hydrobromide + Barbiturates— Promethazine may increase, prolong, or intensify sedative action. Dose should be reduced by at least one-half when given…
- Promethazine Hydrochloride And Dextromethorphan Hydrobromide + Opioid Analgesics— Promethazine may increase, prolong, or intensify sedative action. Dose reduction recommended when given concomitantly.
- Promethazine Hydrochloride And Dextromethorphan Hydrobromide + Sedatives— Promethazine may increase, prolong, or intensify sedative action of these agents.
- Promethazine Hydrochloride And Dextromethorphan Hydrobromide + Topical Local Anesthetics— Promethazine may increase, prolong, or intensify sedative action of general anesthetics.
- Promethazine Hydrochloride And Dextromethorphan Hydrobromide + Tranquilizers— Promethazine may increase, prolong, or intensify sedative action of tranquilizers.