Does Promethazine Hydrochloride And Dextromethorphan Hydrobromide Interact with Mao Inhibitors?
CDI records a contraindicated classification for Promethazine Hydrochloride And Dextromethorphan Hydrobromide and Mao Inhibitors. The stored summary is: Hyperpyrexia, hypotension, and death have been reported with coadministration of MAO inhibitors and dextromethorphan. Concomitant administration should be avoided. The mechanism involves increased serotonergic activity; increased incidence of extrapyramidal effects reported with phenothiazines and maois. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Contraindicated
- Management
- Do not take together
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
Increased serotonergic activity; increased incidence of extrapyramidal effects reported with phenothiazines and MAOIs
What To Tell Your Doctor or Pharmacist
If you are taking Promethazine Hydrochloride And Dextromethorphan Hydrobromide and your doctor is considering prescribing Mao Inhibitors (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask about alternative medications that do not interact with your current regimen
- Ask how frequently you should be monitored while these are co-prescribed
- Never stop or change either medication without first consulting your healthcare provider