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Does Promethazine Hydrochloride And Dextromethorphan Hydrobromide Interact with Mao Inhibitors?

Promethazine Hydrochloride And Dextromethorphan Hydrobromide and Mao Inhibitors have a contraindicated drug interaction according to U.S. FDA drug labeling data. Hyperpyrexia, hypotension, and death have been reported with coadministration of MAO inhibitors and dextromethorphan. Concomitant administration should be avoided. The mechanism involves increased serotonergic activity; increased incidence of extrapyramidal effects reported with phenothiazines and maois. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Contraindicated
Management
Do not take together
Data Source
U.S. FDA via OpenFDA

How This Interaction Works

The interaction between Promethazine Hydrochloride And Dextromethorphan Hydrobromide and Mao Inhibitors occurs because increased serotonergic activity; increased incidence of extrapyramidal effects reported with phenothiazines and maois. Clinically, this means hyperpyrexia, hypotension, and death have been reported with coadministration of mao inhibitors and dextromethorphan. concomitant administration should be avoided. Because of the severity of this interaction, these medications are contraindicated — meaning they should not be taken together under any circumstances. If you are currently taking both, contact your healthcare provider immediately to discuss alternatives.

What To Tell Your Doctor or Pharmacist

If you are taking Promethazine Hydrochloride And Dextromethorphan Hydrobromide and your doctor is considering prescribing Mao Inhibitors (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask about alternative medications that do not interact with your current regimen
  • Ask how frequently you should be monitored while these are co-prescribed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Promethazine Hydrochloride And Dextromethorphan Hydrobromide(Promethazine Hydrochloride And Dextromethorphan Hydrobromide)+💊 Mao Inhibitors

Severity & Interaction Details

⛔
contraindicated
Avoid this combination
FDA labeling lists this pair as contraindicated. The risk outweighs the benefit in nearly all cases.
Severity scale
MinorContra
On record
Yes
Drug A class
—
Drug B class
—
Source
NLP:promethazine hydrochloride and dextromethorphan hydrobromide

What this means in plain English

Hyperpyrexia, hypotension, and death have been reported with coadministration of MAO inhibitors and dextromethorphan. Concomitant administration should be avoided.

What the FDA label says

"Increased serotonergic activity; increased incidence of extrapyramidal effects reported with phenothiazines and MAOIs"

📖 Source: NLP:promethazine hydrochloride and dextromethorphan hydrobromide

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Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.