Amiloride Hydrochloride And Hydrochlorothiazide has 17 known drug interactions based on U.S. FDA drug labeling data. 4 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Angiotensin Ii, Cyclosporine, Lithium. Patients taking Amiloride Hydrochloride And Hydrochlorothiazide should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 17
- Major
- 4
- Moderate
- 11
- Minor
- 1
Major (4)
- Amiloride Hydrochloride And Hydrochlorothiazide + Angiotensin Ii— Risk of hyperkalemia may be increased when amiloride HCl is administered concomitantly. Use with caution and frequent mo…
- Amiloride Hydrochloride And Hydrochlorothiazide + Cyclosporine— Risk of hyperkalemia may be increased when amiloride HCl is administered concomitantly. Use with caution and frequent mo…
- Amiloride Hydrochloride And Hydrochlorothiazide + Lithium— Generally should not be given with diuretics. Diuretic agents reduce the renal clearance of lithium and add a high risk …
- Amiloride Hydrochloride And Hydrochlorothiazide + Tacrolimus— Risk of hyperkalemia may be increased when amiloride HCl is administered concomitantly. Use with caution and frequent mo…
Moderate (11)
- Amiloride Hydrochloride And Hydrochlorothiazide + Alcohol— Potentiation of orthostatic hypotension may occur when given concurrently with hydrochlorothiazide.
- Amiloride Hydrochloride And Hydrochlorothiazide + Barbiturates— Potentiation of orthostatic hypotension may occur when given concurrently with hydrochlorothiazide.
- Amiloride Hydrochloride And Hydrochlorothiazide + Cholestyramine Light— Absorption of hydrochlorothiazide is impaired; single doses bind hydrochlorothiazide and reduce its absorption by up to …
- Amiloride Hydrochloride And Hydrochlorothiazide + Colestipol— Absorption of hydrochlorothiazide is impaired; single doses bind hydrochlorothiazide and reduce its absorption by up to …
- Amiloride Hydrochloride And Hydrochlorothiazide + Corticosteroids— Intensified electrolyte depletion, particularly hypokalemia, may occur when used concurrently with hydrochlorothiazide.
- Amiloride Hydrochloride And Hydrochlorothiazide + Indomethacin— Both indomethacin and potassium-sparing diuretics may increase serum potassium levels. Consider effects on potassium kin…
- Amiloride Hydrochloride And Hydrochlorothiazide + Insulin Degludec And Liraglutide— Dosage adjustment of the antidiabetic drug may be required when used with hydrochlorothiazide.
- Amiloride Hydrochloride And Hydrochlorothiazide + Nonsteroidal Anti-Inflammatory Drugs (Nsaids)— NSAIAs may reduce diuretic, natriuretic, and antihypertensive effects. Patient should be observed closely to determine i…
- Amiloride Hydrochloride And Hydrochlorothiazide + Other Anticholinergic Agents— Additive effect or potentiation may occur when used concurrently with hydrochlorothiazide.
- Amiloride Hydrochloride And Hydrochlorothiazide + Repository Corticotropin— Intensified electrolyte depletion, particularly hypokalemia, may occur when used concurrently with hydrochlorothiazide.
- Amiloride Hydrochloride And Hydrochlorothiazide + Tubocurarine— Possible increased responsiveness to nondepolarizing skeletal muscle relaxants when used with hydrochlorothiazide.
Minor (1)
- Amiloride Hydrochloride And Hydrochlorothiazide + Norepinephrine— Possible decreased response to pressor amines but not sufficient to preclude their use.