Does Amiloride Hydrochloride And Hydrochlorothiazide Interact with Cholestyramine Light?
Amiloride Hydrochloride And Hydrochlorothiazide and Cholestyramine Light have a moderate drug interaction according to U.S. FDA drug labeling data. Absorption of hydrochlorothiazide is impaired; single doses bind hydrochlorothiazide and reduce its absorption by up to 85 percent. The mechanism involves reduced gastrointestinal absorption of hydrochlorothiazide. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Moderate
- Amiloride Hydrochloride And Hydrochlorothiazide Class
- Thiazide Diuretic
- Cholestyramine Light Class
- Bile Acid Sequestrant
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
How This Interaction Works
The interaction between Amiloride Hydrochloride And Hydrochlorothiazide and Cholestyramine Light occurs because reduced gastrointestinal absorption of hydrochlorothiazide. Clinically, this means absorption of hydrochlorothiazide is impaired; single doses bind hydrochlorothiazide and reduce its absorption by up to 85 percent. This is classified as a moderate interaction. While it may not require stopping either medication, your healthcare provider should be aware you are taking both so they can monitor for potential effects and adjust treatment if necessary.
What To Tell Your Doctor or Pharmacist
If you are taking Amiloride Hydrochloride And Hydrochlorothiazide and your doctor is considering prescribing Cholestyramine Light (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider