Glyburide And Metformin Hydrochloride

Concomitant administration is contraindicated due to increased risk of liver enzyme elevations.

Carbonic anhydrase inhibitor that decreases serum bicarbonate and may increase risk for lactic acidosis when used with glyburide and metformin hydrochloride.

Chloramphenicol may potentiate the hypoglycemic action of glyburide. Close observation for hypoglycemia required.

Reduces metformin clearance and may increase risk for lactic acidosis.

Carbonic anhydrase inhibitor that decreases serum bicarbonate and may increase risk for lactic acidosis when used with glyburide and metformin hydrochloride.

OCT2/MATE inhibitor that reduces metformin clearance and may increase risk for lactic acidosis.

A potential interaction between oral miconazole and oral hypoglycemic agents leading to severe hypoglycemia has been reported. Whether this interaction also occurs with the intravenous, topical, or vaginal preparations of miconazole is not known.

Monoamine oxidase inhibitors may potentiate the hypoglycemic action of glyburide. Close observation for hypoglycemia required.

Beta-adrenergic blocking agents may potentiate the hypoglycemic action of glyburide. Close observation for hypoglycemia required.

Coumarins may potentiate the hypoglycemic action of glyburide. Close observation for hypoglycemia required.

Probenecid may potentiate the hypoglycemic action of glyburide. Close observation for hypoglycemia required.

OCT2/MATE inhibitor that reduces metformin clearance and may increase risk for lactic acidosis.

Salicylates may potentiate the hypoglycemic action of glyburide. Close observation for hypoglycemia required.

Carbonic anhydrase inhibitor that decreases serum bicarbonate and may increase risk for lactic acidosis when used with glyburide and metformin hydrochloride.

OCT2/MATE inhibitor that reduces metformin clearance and may increase risk for lactic acidosis.

Carbonic anhydrase inhibitor that decreases serum bicarbonate and may increase risk for lactic acidosis when used with glyburide and metformin hydrochloride.

Potentiates the effect of metformin on lactate metabolism, increasing lactic acidosis risk.

Thiazide diuretics tend to produce hyperglycemia and may lead to loss of blood glucose control. Close observation required.

Calcium channel blocking drugs tend to produce hyperglycemia and may lead to loss of blood glucose control. Close observation required.

Potentially may potentiate hypoglycemic action of glyburide; monitor closely for hypoglycemia.

May reduce glyburide absorption by 32-47%; administer glyburide and metformin at least 4 hours prior to colesevelam.

Corticosteroids tend to produce hyperglycemia and may lead to loss of blood glucose control. Close observation required.

Estrogens tend to produce hyperglycemia and may lead to loss of blood glucose control. Close observation required.

Furosemide increases metformin plasma and blood C max by 22% and blood AUC by 15%. Pharmacokinetic parameters of both drugs are affected.

Isoniazid tends to produce hyperglycemia and may lead to loss of blood glucose control. Close observation required.

Nicotinic acid tends to produce hyperglycemia and may lead to loss of blood glucose control. Close observation required.

Oral contraceptives tend to produce hyperglycemia and may lead to loss of blood glucose control. Close observation required.

Phenothiazines tend to produce hyperglycemia and may lead to loss of blood glucose control. Close observation required.

Phenytoin tends to produce hyperglycemia and may lead to loss of blood glucose control. Close observation required.

Thiazide diuretics tend to produce hyperglycemia and may lead to loss of glycemic control.

Thyroid products tend to produce hyperglycemia and may lead to loss of blood glucose control. Close observation required.

Nifedipine A single-dose, metformin-nifedipine drug interaction study in normal healthy volunteers demonstrated that coadministration of nifedipine increased plasma metformin C max and AUC by 20% and 9%, respectively, and increased the amount excreted in the urine. Nifedipine appears to enhance the absorption of metformin. Metformin had minimal effects on nifedipine.

Cationic drugs Cationic drugs (eg, amiloride, digoxin, morphine, procainamide, quinidine, quinine, ranitidine, triamterene, trimethoprim, or vancomycin) that are eliminated by renal tubular secretion theoretically have the potential for interaction with metformin by competing for common renal tubular transport systems.

Other In healthy volunteers, the pharmacokinetics of metformin and propranolol and metformin and ibuprofen were not affected when coadministered in single-dose interaction studies.

Cationic drugs Cationic drugs (eg, amiloride, digoxin, morphine, procainamide, quinidine, quinine, ranitidine, triamterene, trimethoprim, or vancomycin) that are eliminated by renal tubular secretion theoretically have the potential for interaction with metformin by competing for common renal tubular transport systems.