Does Colesevelam Interact with Glyburide And Metformin Hydrochloride?
CDI records a moderate classification for Colesevelam and Glyburide And Metformin Hydrochloride. The stored summary is: May reduce glyburide absorption by 32-47%; administer glyburide and metformin at least 4 hours prior to colesevelam. The mechanism involves reduces glyburide bioavailability. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Moderate
- Glyburide And Metformin Hydrochloride Class
- Sulfonylurea
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
Reduces glyburide bioavailability
What To Tell Your Doctor or Pharmacist
If you are taking Colesevelam and your doctor is considering prescribing Glyburide And Metformin Hydrochloride (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider