Insulin Glargine has 40 known drug interactions based on U.S. FDA drug labeling data. 22 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Albuterol, Clozapine, Corticosteroids. Patients taking Insulin Glargine should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 40
- Major
- 22
- Moderate
- 16
Major (22)
- Insulin Glargine + Albuterol— May decrease blood glucose lowering effect of LANTUS. Dosage increases and increased glucose monitoring may be required.
- Insulin Glargine + Clozapine— May decrease blood glucose lowering effect of LANTUS. Dosage increases and increased glucose monitoring may be required.
- Insulin Glargine + Corticosteroids— May decrease blood glucose lowering effect of LANTUS. Dosage increases and increased glucose monitoring may be required.
- Insulin Glargine + Danazol— May decrease blood glucose lowering effect of LANTUS. Dosage increases and increased glucose monitoring may be required.
- Insulin Glargine + Disopyramide— May increase risk of hypoglycemia. Dosage reductions and increased glucose monitoring may be required.
- Insulin Glargine + Diuretics— May decrease blood glucose lowering effect of LANTUS. Dosage increases and increased glucose monitoring may be required.
- Insulin Glargine + Epinephrine— May decrease blood glucose lowering effect of LANTUS. Dosage increases and increased glucose monitoring may be required.
- Insulin Glargine + Estrogens— May decrease blood glucose lowering effect of LANTUS. Dosage increases and increased glucose monitoring may be required.
- Insulin Glargine + Fibrates— May increase risk of hypoglycemia. Dosage reductions and increased glucose monitoring may be required.
- Insulin Glargine + Fluoxetine— May increase risk of hypoglycemia. Dosage reductions and increased glucose monitoring may be required.
- Insulin Glargine + Glucagon— May decrease blood glucose lowering effect of LANTUS. Dosage increases and increased glucose monitoring may be required.
- Insulin Glargine + Isoniazid— May decrease blood glucose lowering effect of LANTUS. Dosage increases and increased glucose monitoring may be required.
- Insulin Glargine + Niacin— May decrease blood glucose lowering effect of LANTUS. Dosage increases and increased glucose monitoring may be required.
- Insulin Glargine + Octreotide— May increase risk of hypoglycemia. Dosage reductions and increased glucose monitoring may be required.
- Insulin Glargine + Olanzapine— May decrease blood glucose lowering effect of LANTUS. Dosage increases and increased glucose monitoring may be required.
- Insulin Glargine + Pentoxifylline— May increase risk of hypoglycemia. Dosage reductions and increased glucose monitoring may be required.
- Insulin Glargine + Phenothiazines— May decrease blood glucose lowering effect of LANTUS. Dosage increases and increased glucose monitoring may be required.
- Insulin Glargine + Pramlintide— May increase risk of hypoglycemia. Dosage reductions and increased glucose monitoring may be required.
- Insulin Glargine + Salicylates— May increase risk of hypoglycemia. Dosage reductions and increased glucose monitoring may be required.
- Insulin Glargine + Somatropin— May decrease blood glucose lowering effect of LANTUS. Dosage increases and increased glucose monitoring may be required.
- Insulin Glargine + Terbutaline— May decrease blood glucose lowering effect of LANTUS. Dosage increases and increased glucose monitoring may be required.
- Insulin Glargine + Thyroid Hormones— May decrease blood glucose lowering effect of LANTUS. Dosage increases and increased glucose monitoring may be required.
Moderate (16)
- Insulin Glargine + Acidifying Agents— May increase risk of hypoglycemia; dose reductions and increased glucose monitoring may be required.
- Insulin Glargine + Alcohol— May increase or decrease blood glucose lowering effect; dosage adjustment and increased glucose monitoring may be requir…
- Insulin Glargine + Angiotensin Ii— May increase risk of hypoglycemia. Dosage reductions and increased glucose monitoring may be required.
- Insulin Glargine + Clonidine— May increase or decrease blood glucose lowering effect and blunt signs/symptoms of hypoglycemia. Dosage adjustment and i…
- Insulin Glargine + Guanethidine— May blunt signs and symptoms of hypoglycemia; increased glucose monitoring may be required.
- Insulin Glargine + Latanoprost Ophthalmic Solution 0.005%— Combined use of two or more prostaglandins or prostaglandin analogs not recommended. Administration more than once daily…
- Insulin Glargine + Liraglutide— May increase risk of hypoglycemia. Dosage reductions and increased glucose monitoring may be required.
- Insulin Glargine + Lithium— May increase or decrease blood glucose lowering effect; dosage adjustment and increased glucose monitoring may be requir…
- Insulin Glargine + Macrolide Antibiotics— May increase risk of hypoglycemia. Dosage reductions and increased glucose monitoring may be required.
- Insulin Glargine + Mao Inhibitors— May increase risk of hypoglycemia. Dosage reductions and increased glucose monitoring may be required.
- Insulin Glargine + Monoamine Oxidase Inhibitors (Maois)— May increase risk of hypoglycemia. Dosage reductions and increased glucose monitoring may be required.
- Insulin Glargine + Nonselective Beta-Adrenergic Antagonists— May increase or decrease blood glucose lowering effect and blunt signs/symptoms of hypoglycemia. Dosage adjustment and i…
- Insulin Glargine + Oral Contraceptives— May decrease blood glucose lowering effect. Dosage increases and increased glucose monitoring may be required.
- Insulin Glargine + Pentamidine— May cause hypoglycemia followed by hyperglycemia; dosage adjustment and increased glucose monitoring may be required.
- Insulin Glargine + Protease Inhibitors— May decrease blood glucose lowering effect. Dosage increases and increased glucose monitoring may be required.
- Insulin Glargine + Reserpine— May blunt signs and symptoms of hypoglycemia; increased glucose monitoring may be required.