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Does Insulin Glargine Interact with Latanoprost Ophthalmic Solution 0005?

Insulin Glargine and Latanoprost Ophthalmic Solution 0005 have a moderate drug interaction according to U.S. FDA drug labeling data. Combined use of two or more prostaglandins or prostaglandin analogs not recommended. Administration more than once daily may decrease IOP lowering effect or cause paradoxical IOP elevations. The mechanism involves unknown mechanism for iop effect reduction or paradoxical elevation. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Moderate
Insulin Glargine Class
Insulin Analog
Latanoprost Ophthalmic Solution 0005 Class
Prostaglandin Analog
Management
Monitor for effects
Data Source
U.S. FDA via OpenFDA

How This Interaction Works

The interaction between Insulin Glargine and Latanoprost Ophthalmic Solution 0005 occurs because unknown mechanism for iop effect reduction or paradoxical elevation. Clinically, this means combined use of two or more prostaglandins or prostaglandin analogs not recommended. administration more than once daily may decrease iop lowering effect or cause paradoxical iop elevations. This is classified as a moderate interaction. While it may not require stopping either medication, your healthcare provider should be aware you are taking both so they can monitor for potential effects and adjust treatment if necessary.

What To Tell Your Doctor or Pharmacist

If you are taking Insulin Glargine and your doctor is considering prescribing Latanoprost Ophthalmic Solution 0005 (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask whether any dosage adjustments are needed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Insulin Glargine(Basaglar Kwikpen)+💊 Latanoprost Ophthalmic Solution 0005(Iyuzeh)

Severity & Interaction Details

🟡
moderate
Be aware — moderate interaction
Documented interaction with manageable risk. May require dose adjustment or monitoring.
Severity scale
MinorContra
On record
Yes
Drug A class
Insulin Analog
Drug B class
Prostaglandin Analog
Source
NLP:latanoprost ophthalmic solution 0.005%

What this means in plain English

Combined use of two or more prostaglandins or prostaglandin analogs not recommended. Administration more than once daily may decrease IOP lowering effect or cause paradoxical IOP elevations.

What the FDA label says

"Unknown mechanism for IOP effect reduction or paradoxical elevation"

📖 Source: NLP:latanoprost ophthalmic solution 0.005%

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Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.