Isosorbide Mononitrate has 4 known drug interactions based on U.S. FDA drug labeling data. Of these, 2 are contraindicated combinations that should be avoided entirely. 1 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Mao Inhibitors, Riociguat, Calcium Channel Blockers. Patients taking Isosorbide Mononitrate should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 4
- Contraindicated
- 2
- Major
- 1
- Moderate
- 1
Contraindicated (2)
- Isosorbide Mononitrate + Mao Inhibitors— Concomitant use of isosorbide mononitrate with phosphodiesterase inhibitors in any form is contraindicated.
- Isosorbide Mononitrate + Riociguat— Concomitant use of isosorbide mononitrate with riociguat, a soluble guanylate cyclase stimulator, is contraindicated.
Major (1)
- Isosorbide Mononitrate + Calcium Channel Blockers— Marked symptomatic orthostatic hypotension reported when combined with organic nitrates. Dose adjustments of either agen…
Moderate (1)
- Isosorbide Mononitrate + Alcohol— Alcohol exhibits additive vasodilating effects with isosorbide mononitrate, potentially causing additive hypotensive eff…