Does Riociguat Interact with Isosorbide Mononitrate?
CDI records a contraindicated classification for Riociguat and Isosorbide Mononitrate. The stored summary is: Concomitant use of isosorbide mononitrate with riociguat, a soluble guanylate cyclase stimulator, is contraindicated. The mechanism involves soluble guanylate cyclase stimulation. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Contraindicated
- Riociguat Class
- Soluble Guanylate Cyclase Stimulator
- Isosorbide Mononitrate Class
- Nitrate Vasodilator
- Management
- Do not take together
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
soluble guanylate cyclase stimulation
What To Tell Your Doctor or Pharmacist
If you are taking Riociguat and your doctor is considering prescribing Isosorbide Mononitrate (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask about alternative medications that do not interact with your current regimen
- Ask how frequently you should be monitored while these are co-prescribed
- Never stop or change either medication without first consulting your healthcare provider