Amantadine Hydrochloride has 10 known drug interactions based on U.S. FDA drug labeling data. Of these, 1 are contraindicated combinations that should be avoided entirely. 1 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Live Attenuated Vaccines, Thioridazine, Acidifying Agents. Patients taking Amantadine Hydrochloride should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 10
- Contraindicated
- 1
- Major
- 1
- Moderate
- 8
Contraindicated (1)
- Amantadine Hydrochloride + Live Attenuated Vaccines— Should not be administered within 2 weeks before or 48 hours after amantadine hydrochloride due to potential interferenc…
Major (1)
- Amantadine Hydrochloride + Thioridazine— Coadministration of thioridazine has been reported to worsen the tremor in elderly patients with Parkinson's disease.
Moderate (8)
- Amantadine Hydrochloride + Acidifying Agents— May potentiate the anticholinergic-like side effects of amantadine hydrochloride.
- Amantadine Hydrochloride + Cns Stimulants— Careful observation required when administered concurrently with amantadine hydrochloride.
- Amantadine Hydrochloride + Drugs With Potential For Inducing Orthostatic Hypotension— Agents with anticholinergic properties may potentiate the anticholinergic-like side effects of amantadine.
- Amantadine Hydrochloride + Hydrochlorothiazide— Coadministration resulted in higher plasma amantadine concentration; monitor amantadine levels.
- Amantadine Hydrochloride + Quinidine— Reduces renal clearance of amantadine hydrochloride by approximately 30%.
- Amantadine Hydrochloride + Quinine— Reduces renal clearance of amantadine hydrochloride by approximately 30%.
- Amantadine Hydrochloride + Triamterene— Coadministration resulted in higher plasma amantadine concentration; monitor amantadine levels.
- Amantadine Hydrochloride + Triamterene And Hydrochlorothiazide— Coadministration resulted in higher plasma amantadine hydrochloride concentration in a 61-year-old patient; unclear whic…