Does Amantadine Hydrochloride Interact with Hydrochlorothiazide?
CDI records a moderate classification for Amantadine Hydrochloride and Hydrochlorothiazide. The stored summary is: Coadministration resulted in higher plasma amantadine concentration; monitor amantadine levels. The mechanism involves reduced renal clearance of amantadine. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Moderate
- Hydrochlorothiazide Class
- Thiazide Diuretic
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
Reduced renal clearance of amantadine
What To Tell Your Doctor or Pharmacist
If you are taking Amantadine Hydrochloride and your doctor is considering prescribing Hydrochlorothiazide (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider