Atovaquone And Proguanil Hydrochloride has 6 known drug interactions based on U.S. FDA drug labeling data. Of these, 2 are contraindicated combinations that should be avoided entirely. 1 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Rifabutin, Rifampin, Warfarin. Patients taking Atovaquone And Proguanil Hydrochloride should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 6
- Contraindicated
- 2
- Major
- 1
- Moderate
- 3
Contraindicated (2)
- Atovaquone And Proguanil Hydrochloride + Rifabutin— Rifabutin reduces atovaquone concentrations; concomitant use is not recommended.
- Atovaquone And Proguanil Hydrochloride + Rifampin— Rifampin reduces atovaquone concentrations; concomitant use is not recommended.
Major (1)
- Atovaquone And Proguanil Hydrochloride + Warfarin— Proguanil may potentiate the anticoagulant effect of warfarin. Coagulation tests should be closely monitored.
Moderate (3)
- Atovaquone And Proguanil Hydrochloride + Indinavir— 7.5 Indinavir Concomitant administration of atovaquone and indinavir did not result in any change in the steady-state AU…
- Atovaquone And Proguanil Hydrochloride + Metoclopramide— Metoclopramide may reduce bioavailability of atovaquone and should be used only if other antiemetics are not available.
- Atovaquone And Proguanil Hydrochloride + Tetracycline— Tetracycline reduces plasma concentrations of atovaquone. Parasitemia should be closely monitored.