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Does Atovaquone And Proguanil Hydrochloride Interact with Rifampin?

Atovaquone And Proguanil Hydrochloride and Rifampin have a contraindicated drug interaction according to U.S. FDA drug labeling data. Rifampin reduces atovaquone concentrations; concomitant use is not recommended. The mechanism involves reduction of atovaquone concentrations. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Contraindicated
Atovaquone And Proguanil Hydrochloride Class
Antimalarial
Rifampin Class
Rifamycin Antibacterial
Management
Do not take together
Data Source
U.S. FDA via OpenFDA

How This Interaction Works

The interaction between Atovaquone And Proguanil Hydrochloride and Rifampin occurs because reduction of atovaquone concentrations. Clinically, this means rifampin reduces atovaquone concentrations; concomitant use is not recommended. Because of the severity of this interaction, these medications are contraindicated — meaning they should not be taken together under any circumstances. If you are currently taking both, contact your healthcare provider immediately to discuss alternatives.

What To Tell Your Doctor or Pharmacist

If you are taking Atovaquone And Proguanil Hydrochloride and your doctor is considering prescribing Rifampin (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask about alternative medications that do not interact with your current regimen
  • Ask how frequently you should be monitored while these are co-prescribed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Atovaquone And Proguanil Hydrochloride(Atovaquone And Proguanil Hcl)+💊 Rifampin(Rifampin)

Severity & Interaction Details

⛔
contraindicated
Avoid this combination
FDA labeling lists this pair as contraindicated. The risk outweighs the benefit in nearly all cases.
Severity scale
MinorContra
On record
Yes
Drug A class
Antimalarial
Drug B class
Rifamycin Antibacterial
Source
NLP:atovaquone and proguanil hydrochloride

What this means in plain English

Rifampin reduces atovaquone concentrations; concomitant use is not recommended.

What the FDA label says

"Reduction of atovaquone concentrations"

📖 Source: NLP:atovaquone and proguanil hydrochloride

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Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.