Does Atovaquone And Proguanil Hydrochloride Interact with Rifampin?
CDI records a contraindicated classification for Atovaquone And Proguanil Hydrochloride and Rifampin. The stored summary is: Rifampin reduces atovaquone concentrations; concomitant use is not recommended. The mechanism involves reduction of atovaquone concentrations. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Contraindicated
- Atovaquone And Proguanil Hydrochloride Class
- Antimalarial
- Rifampin Class
- Rifamycin Antibacterial
- Management
- Do not take together
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
Reduction of atovaquone concentrations
What To Tell Your Doctor or Pharmacist
If you are taking Atovaquone And Proguanil Hydrochloride and your doctor is considering prescribing Rifampin (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask about alternative medications that do not interact with your current regimen
- Ask how frequently you should be monitored while these are co-prescribed
- Never stop or change either medication without first consulting your healthcare provider