Dapsone has 67 known drug interactions based on U.S. FDA drug labeling data. 50 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Acetaminophen, Acetanilide, Acetazolamide. Patients taking Dapsone should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 67
- Major
- 50
- Moderate
- 13
- Minor
- 2
Major (50)
- Dapsone + Acetaminophen— Induces methemoglobinemia; concomitant use may increase risk for developing methemoglobinemia.
- Dapsone + Acetanilide— Induces methemoglobinemia; concomitant use may increase risk for developing methemoglobinemia.
- Dapsone + Acetazolamide— Drugs that induce methemoglobinemia; concomitant use may increase risk for developing methemoglobinemia.
- Dapsone + Aniline Dyes— Concomitant use may increase risk of methemoglobinemia.
- Dapsone + Articaine Hydrochloride And Epinephrine— Increased risk of methemoglobinemia when concurrently exposed to articaine.
- Dapsone + Articaine Hydrochloride And Epinephrine Bitartrate— Increased risk of developing methemoglobinemia when concurrently exposed to this antibiotic.
- Dapsone + Benzocaine— Induces methemoglobinemia; concomitant use may increase risk for developing methemoglobinemia.
- Dapsone + Benzocaine, Butamben, And Tetracaine Hydrochloride— Increased risk of methemoglobinemia when concurrently exposed to this antibiotic oxidizing agent with local anesthetics.
- Dapsone + Bupivacaine And Meloxicam— Increased risk of methemoglobinemia when local anesthetics are used concomitantly with antibiotics.
- Dapsone + Bupivacaine Hydrochloride— Increased risk of methemoglobinemia when concurrently exposed with bupivacaine.
- Dapsone + Chloroquine— Induces methemoglobinemia; concomitant use may increase risk for developing methemoglobinemia.
- Dapsone + Dexamethasone Sodium Phosphate, Lidocaine Hydrochloride, Povidine Iodine— Antibiotic associated with increased methemoglobinemia risk when used with ropivacaine.
- Dapsone + Ganciclovir Sodium— Associated with myelosuppression or nephrotoxicity; coadministration should be considered only if potential benefits out…
- Dapsone + Lidocaine— Increased risk of methemoglobinemia when used concurrently with lidocaine.
- Dapsone + Lidocaine 5%— Antibiotic that may cause methemoglobinemia when used concomitantly with lidocaine patch 5%.
- Dapsone + Lidocaine And Capsaicin— Antibiotic that increases risk of methemoglobinemia when used concurrently with lidocaine and capsaicin patch.
- Dapsone + Lidocaine And Prilocaine— Antibiotic; increased risk of methemoglobinemia when concurrently exposed.
- Dapsone + Lidocaine Hydrochloride— Increased risk of methemoglobinemia when used concurrently with lidocaine hydrochloride.
- Dapsone + Lidocaine Hydrochloride And Epinephrine Bitartrate— Antibiotic associated with increased methemoglobinemia risk when used concurrently.
- Dapsone + Lidocaine Hydrochloride And Hydrocortisone Acetate— Increased risk of methemoglobinemia when local anesthetic is concurrently exposed to antibiotics.
- Dapsone + Lidocaine Hydrochloride Monohydrate— Concurrent exposure increases risk of methemoglobinemia in patients administered local anesthetics.
- Dapsone + Lidocaine Patch 5%— Increased risk of methemoglobinemia; antibiotics associated with methemoglobinemia when used with local anesthetics.
- Dapsone + Lidocaine, Isopropyl Alcohol— Increased risk of methemoglobinemia when used with lidocaine.
- Dapsone + Lidocaine, Menthol— Increased risk of methemoglobinemia when lidocaine is concurrently exposed to antibiotics.
- Dapsone + Lidothol Patch— Increased risk of methemoglobinemia when local anesthetics are concurrently exposed to antibiotics.
- Dapsone + Marcaine, Lidocaine, Kenalog, Povidone Iodine— Increased risk of methemoglobinemia when concurrently exposed to antibiotics.
- Dapsone + Mepivacaine Hydrochloride— Concurrent exposure increases risk of methemoglobinemia in patients administered mepivacaine.
- Dapsone + Methotrexate— Antifolate drug that may increase methotrexate plasma concentrations, increasing risk of severe adverse reactions and po…
- Dapsone + Methotrexate Sodium— Antifolate drug that may increase methotrexate plasma concentrations, increasing risk of severe adverse reactions and po…
- Dapsone + Naphthalene— Concomitant use may increase risk of methemoglobinemia.
- Dapsone + Nitrates— Concomitant use may increase risk of methemoglobinemia.
- Dapsone + Nitrites— Concomitant use may increase risk of methemoglobinemia.
- Dapsone + Nitrofurantoin— Induces methemoglobinemia; concomitant use may increase risk for developing methemoglobinemia.
- Dapsone + Nitroglycerin— Induces methemoglobinemia; concomitant use may increase risk for developing methemoglobinemia.
- Dapsone + Nitroprusside— Induces methemoglobinemia; concomitant use may increase risk for developing methemoglobinemia.
- Dapsone + Para-Aminosalicylic Acid— Induces methemoglobinemia; concomitant use may increase risk for developing methemoglobinemia.
- Dapsone + Penicillin G Benzathine And Penicillin G Procaine— Increased risk of methemoglobinemia when penicillin is concurrently administered with dapsone (an antibiotic).
- Dapsone + Phenacetin— Induces methemoglobinemia; concomitant use may increase risk for developing methemoglobinemia.
- Dapsone + Phenobarbital— Induces methemoglobinemia; concomitant use may increase risk for developing methemoglobinemia.
- Dapsone + Phenytoin— Induces methemoglobinemia; concomitant use may increase risk for developing methemoglobinemia.
- Dapsone + Prilocaine Hcl And Epinephrine— Increased risk of methemoglobinemia when prilocaine is concurrently exposed to dapsone.
- Dapsone + Prilocaine Hydrochloride— Increased risk of methemoglobinemia when used concurrently with prilocaine.
- Dapsone + Primaquine— Induces methemoglobinemia; concomitant use may increase risk for developing methemoglobinemia.
- Dapsone + Quinine— Induces methemoglobinemia; concomitant use may increase risk for developing methemoglobinemia.
- Dapsone + Ropivacaine Hydrochloride— Increased risk of developing methemoglobinemia when concurrently exposed to dapsone.
- Dapsone + Triamcinolone Acetonide— Increased risk of methemoglobinemia when concurrently exposed.
- Dapsone + Triethanolamine Salicylate— Increased risk of methemoglobinemia when used concurrently with triethanolamine salicylate.
- Dapsone + Trubrexa Patch Er— Increased risk of methemoglobinemia when used with Trubrexa Transdermal Patch.
- Dapsone + Valganciclovir— Associated with myelosuppression or nephrotoxicity. Coadministration should be considered only if potential benefits out…
- Dapsone + Valganciclovir Hydrochloride— Co-administration with valganciclovir should be considered only if potential benefits outweigh risks due to potential fo…
Moderate (13)
- Dapsone + Bupivacaine— May increase risk of methemoglobinemia when concurrently exposed with bupivacaine.
- Dapsone + Bupivacaine Hydrochloride And Epinephrine Bitartrate— Increased risk of methemoglobinemia when concurrently exposed.
- Dapsone + Bupivacaine Hydrochloride With Dextrose— Increased risk of developing methemoglobinemia when concurrently exposed.
- Dapsone + Ganciclovir— Associated with myelosuppression or nephrotoxicity. Coadministration considered only if benefits outweigh risks.
- Dapsone + Lidocaine And Tetracaine— Antibiotic that increases risk of methemoglobinemia when used concomitantly with lidocaine and tetracaine.
- Dapsone + Marcaine, Kenalog, Povidone Iodine— Increased risk of methemoglobinemia when concurrently exposed to antibiotics with bupivacaine.
- Dapsone + Oral Anticoagulants— May increase formation of dapsone hydroxylamine, a metabolite associated with hemolysis. Monitor for hemolytic reactions…
- Dapsone + Pyrimethamine— Folic acid antagonist that may increase the likelihood of hematologic reactions when used with oral dapsone.
- Dapsone + Rifampin— May increase formation of dapsone hydroxylamine, a metabolite associated with hemolysis. Monitor for hemolytic reactions…
- Dapsone + Rifapentine— Rifapentine may increase metabolism and decrease activity. Dosage adjustment may be necessary.
- Dapsone + St. John'S Wort— May increase formation of dapsone hydroxylamine, a metabolite associated with hemolysis. Monitor for hemolytic reactions…
- Dapsone + Sulfamethoxazole And Trimethoprim— TMP/SMX increases systemic levels of dapsone and its metabolites (AUC increased ~40% for dapsone, ~20% for N-acetyldapso…
- Dapsone + Trimethoprim— Mutual interaction where Dapsone and trimethoprim each raise the level of the other approximately 1.5 times; interaction…
Minor (2)
- Dapsone + Benzoyl Peroxide— Topical co-application may result in temporary local yellow or orange skin discoloration and discoloration of facial hai…
- Dapsone + Benzoyl Peroxide (Topical)— Topical application after dapsone may cause temporary local yellow or orange skin discoloration, resolving in 4-57 days.