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Does Benzoyl Peroxide Interact with Dapsone?

Benzoyl Peroxide and Dapsone have a minor drug interaction according to U.S. FDA drug labeling data. Topical co-application may result in temporary local yellow or orange skin discoloration and discoloration of facial hair, resolving within 4-57 days. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Minor
Dapsone Class
Sulfone
Management
Generally manageable
Data Source
U.S. FDA via OpenFDA

What To Tell Your Doctor or Pharmacist

If you are taking Benzoyl Peroxide and your doctor is considering prescribing Dapsone (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Never stop or change either medication without first consulting your healthcare provider
💊 Benzoyl Peroxide(Fostex)+💊 Dapsone(Aczone)

Severity & Interaction Details

✅
minor
Generally safe — minor interaction
Low clinical significance. Routine awareness is usually sufficient.
Severity scale
MinorContra
On record
Yes
Drug A class
—
Drug B class
Sulfone
Source
NLP:dapsone

What this means in plain English

Topical co-application may result in temporary local yellow or orange skin discoloration and discoloration of facial hair, resolving within 4-57 days.

About Benzoyl Peroxide and Dapsone

Dapsone is a Sulfone. You may recognize them by the brand names Fostex and Aczone. Dapsone is taken by mouth.

Recent research & FDA safety updates

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Auto-aggregated from PubMed E-utilities and FDA safety data.

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Data integrity: Every interaction shown is extracted directly from official U.S. FDA drug labeling via openFDA and the U.S. National Library of Medicine (NIH) — no interactions are invented, inferred, or manually edited. Maintained by CheckDrugInteractions.com. See our methodology or report a correction at support@checkdruginteractions.com.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine, supplemented with a small number of well-established interactions from curated clinical references. For informational purposes only. Always consult your pharmacist or physician.