Nebivolol has 20 known drug interactions based on U.S. FDA drug labeling data. Of these, 1 are contraindicated combinations that should be avoided entirely. 7 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Nebivolol Hydrochloride, Clonidine, Digitalis Glycosides. Patients taking Nebivolol should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 20
- Contraindicated
- 1
- Major
- 7
- Moderate
- 9
Contraindicated (1)
- Nebivolol + Nebivolol Hydrochloride— 7 DRUG INTERACTIONS • CYP2D6 enzyme inhibitors may increase nebivolol levels. ( 7.4 ) 7.1 CYP2D6 Inhibitors Use caution …
Major (7)
- Nebivolol + Clonidine— Discontinue nebivolol several days before gradual tapering of clonidine to avoid excessive reduction of sympathetic acti…
- Nebivolol + Digitalis Glycosides— Both slow atrioventricular conduction and decrease heart rate; concomitant use increases risk of bradycardia.
- Nebivolol + Diltiazem— Calcium channel blocker that may cause excessive reductions in heart rate, blood pressure, and cardiac contractility.
- Nebivolol + Disopyramide— Antiarrhythmic agent; nebivolol can exacerbate its effects on myocardial depression and AV conduction.
- Nebivolol + Guanethidine— Catecholamine-depleting drug; concomitant use may produce excessive reduction of sympathetic activity. Closely monitor p…
- Nebivolol + Reserpine— Catecholamine-depleting drug; concomitant use may produce excessive reduction of sympathetic activity. Closely monitor p…
- Nebivolol + Verapamil— Calcium channel blocker that may cause excessive reductions in heart rate, blood pressure, and cardiac contractility.
Moderate (9)
- Nebivolol + Desvenlafaxine— Desvenlafaxine increases nebivolol levels. Reduce dose by up to one-half with 400 mg desvenlafaxine; no adjustment neede…
- Nebivolol + Desvenlafaxine Er— Desvenlafaxine increases nebivolol exposure. Reduce dose by up to one-half with 400 mg desvenlafaxine; no adjustment nee…
- Nebivolol + Desvenlafaxine Succinate— Concomitant use increases exposure (Cmax and AUC). Reduce dose by up to one-half if co-administered with 400 mg desvenla…
- Nebivolol + Fluoxetine— CYP2D6 inhibitor that may increase nebivolol levels; use caution when co-administered.
- Nebivolol + Paroxetine— CYP2D6 inhibitor that may increase nebivolol levels; use caution when co-administered.
- Nebivolol + Paroxetine Hydrochloride— Increased exposure of CYP2D6 substrate; decrease dosage if needed.
- Nebivolol + Patiromer— Patiromer binds nebivolol, potentially reducing systemic exposure and clinical efficacy. Separate dosing by at least 3 h…
- Nebivolol + Propafenone— CYP2D6 inhibitor that may increase nebivolol levels; use caution when co-administered.
- Nebivolol + Quinidine— CYP2D6 inhibitor that may increase nebivolol levels; use caution when co-administered.