Does Nebivolol Interact with Desvenlafaxine?
Nebivolol and Desvenlafaxine have a moderate drug interaction according to U.S. FDA drug labeling data. Desvenlafaxine increases nebivolol levels. Reduce dose by up to one-half with 400 mg desvenlafaxine; no adjustment needed with 100 mg or lower. The mechanism involves desvenlafaxine inhibits cyp2d6 metabolism of nebivolol. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Moderate
- Nebivolol Class
- beta-Adrenergic Blocker
- Desvenlafaxine Class
- Serotonin and Norepinephrine Reuptake Inhibitor
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
How This Interaction Works
The interaction between Nebivolol and Desvenlafaxine occurs because desvenlafaxine inhibits cyp2d6 metabolism of nebivolol. Clinically, this means desvenlafaxine increases nebivolol levels. reduce dose by up to one-half with 400 mg desvenlafaxine; no adjustment needed with 100 mg or lower. This is classified as a moderate interaction. While it may not require stopping either medication, your healthcare provider should be aware you are taking both so they can monitor for potential effects and adjust treatment if necessary.
What To Tell Your Doctor or Pharmacist
If you are taking Nebivolol and your doctor is considering prescribing Desvenlafaxine (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider