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Terbinafine Tablets 250 Mg

Also known as: Terbinafine Hydrochloride

Route: Oral

Check Terbinafine Tablets 250 Mg Interactions →

16 interactions on record

Terbinafine Tablets 250 Mg has 16 known drug interactions based on U.S. FDA drug labeling data. Notable interactions include combinations with Amiodarone, Caffeine, Cimetidine. Patients taking Terbinafine Tablets 250 Mg should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.

Total: 16
Moderate: 11

Moderate (11)

Terbinafine Tablets 250 Mg + Amiodarone— As a CYP2C9 and CYP3A4 inhibitor, amiodarone may substantially increase systemic exposure of terbinafine (Cmax and AUC).
Terbinafine Tablets 250 Mg + Caffeine— Terbinafine decreases the clearance of caffeine by 19%.
Terbinafine Tablets 250 Mg + Cimetidine— Cimetidine decreases terbinafine clearance by 33%, increasing terbinafine exposure.
Terbinafine Tablets 250 Mg + Cyclosporine— Terbinafine increases the clearance of cyclosporine by 15%.
Terbinafine Tablets 250 Mg + Desipramine— Terbinafine inhibits CYP450 2D6, resulting in 2-fold increase in Cmax and 5-fold increase in AUC of desipramine. Effects…
Terbinafine Tablets 250 Mg + Dextromethorphan— Terbinafine increases dextromethorphan/dextrorphan metabolite ratio by 16- to 97-fold, potentially converting extensive …
Terbinafine Tablets 250 Mg + Flecainide— Flecainide is predominantly metabolized by CYP450 2D6; terbinafine inhibition may increase exposure. Careful monitoring …
Terbinafine Tablets 250 Mg + Fluconazole— Fluconazole increases terbinafine Cmax by 52% and AUC by 69%. Coadministration requires monitoring.
Terbinafine Tablets 250 Mg + Ketoconazole— As a CYP2C9 and CYP3A4 inhibitor, ketoconazole may substantially increase systemic exposure of terbinafine (Cmax and AUC…
Terbinafine Tablets 250 Mg + Propafenone— Propafenone is predominantly metabolized by CYP450 2D6; terbinafine inhibition may increase exposure. Careful monitoring…
Terbinafine Tablets 250 Mg + Rifampin— Rifampin increases terbinafine clearance by 100%, substantially reducing terbinafine exposure.

Terbinafine Tablets 250 Mg + Amiodarone🟡Moderate

As a CYP2C9 and CYP3A4 inhibitor, amiodarone may substantially increase systemic exposure of terbinafine (Cmax and AUC).

Terbinafine Tablets 250 Mg + Caffeine🟡Moderate

Terbinafine decreases the clearance of caffeine by 19%.

Terbinafine Tablets 250 Mg + Cimetidine🟡Moderate

Cimetidine decreases terbinafine clearance by 33%, increasing terbinafine exposure.

Terbinafine Tablets 250 Mg + Cyclosporine🟡Moderate

Terbinafine increases the clearance of cyclosporine by 15%.

Terbinafine Tablets 250 Mg + Desipramine🟡Moderate

Terbinafine inhibits CYP450 2D6, resulting in 2-fold increase in Cmax and 5-fold increase in AUC of desipramine. Effects persist for 4 weeks after discontinuation.

Terbinafine Tablets 250 Mg + Dextromethorphan🟡Moderate

Terbinafine increases dextromethorphan/dextrorphan metabolite ratio by 16- to 97-fold, potentially converting extensive metabolizers to poor metabolizer status.

Terbinafine Tablets 250 Mg + Flecainide🟡Moderate

Flecainide is predominantly metabolized by CYP450 2D6; terbinafine inhibition may increase exposure. Careful monitoring and dose reduction may be required.

Terbinafine Tablets 250 Mg + Fluconazole🟡Moderate

Fluconazole increases terbinafine Cmax by 52% and AUC by 69%. Coadministration requires monitoring.

Terbinafine Tablets 250 Mg + Ketoconazole🟡Moderate

As a CYP2C9 and CYP3A4 inhibitor, ketoconazole may substantially increase systemic exposure of terbinafine (Cmax and AUC).

Terbinafine Tablets 250 Mg + Propafenone🟡Moderate

Propafenone is predominantly metabolized by CYP450 2D6; terbinafine inhibition may increase exposure. Careful monitoring and dose reduction may be required.

Terbinafine Tablets 250 Mg + Rifampin🟡Moderate

Rifampin increases terbinafine clearance by 100%, substantially reducing terbinafine exposure.

Terbinafine Tablets 250 Mg + Cotrimoxazoleℹ️Unknown

The influence of terbinafine on the pharmacokinetics of fluconazole, cotrimoxazole (trimethoprim and sulfamethoxazole), zidovudine or theophylline was not considered to be clinically significant.

Terbinafine Tablets 250 Mg + Fluvastatinℹ️Unknown

In vitro studies with human liver microsomes showed that terbinafine does not inhibit the metabolism of tolbutamide, ethinylestradiol, ethoxycoumarin, cyclosporine, cisapride and fluvastatin.

Terbinafine Tablets 250 Mg + Sulfamethoxazoleℹ️Unknown

The influence of terbinafine on the pharmacokinetics of fluconazole, cotrimoxazole (trimethoprim and sulfamethoxazole), zidovudine or theophylline was not considered to be clinically significant.

Terbinafine Tablets 250 Mg + Tolbutamideℹ️Unknown

In vitro studies with human liver microsomes showed that terbinafine does not inhibit the metabolism of tolbutamide, ethinylestradiol, ethoxycoumarin, cyclosporine, cisapride and fluvastatin.

Terbinafine Tablets 250 Mg + Warfarinℹ️Unknown

Spontaneous reports of increase or decrease in prothrombin times with concomitant use, but causal relationship not established.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.