Digitoxin has 7 known drug interactions based on U.S. FDA drug labeling data. 3 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Colestipol Hydrochloride, Trandolapril And Verapamil Hydrochloride, Verapamil Hydrochloride. Patients taking Digitoxin should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 7
- Major
- 3
- Moderate
- 2
- Minor
- 1
Major (3)
- Digitoxin + Colestipol Hydrochloride— Colestipol may reduce availability of digitoxin with conflicting study results. Particular caution required; discontinui…
- Digitoxin + Trandolapril And Verapamil Hydrochloride— Verapamil reduces total body clearance and extrarenal clearance of digitoxin by 27% and 29%, respectively, risking toxic…
- Digitoxin + Verapamil Hydrochloride— Verapamil reduces total body clearance by 27% and extrarenal clearance by 29%. Maintenance and digitalization doses shou…
Moderate (2)
- Digitoxin + Quinidine Gluconate— Quinidine raises serum digitoxin levels, though the effect appears smaller than with digoxin.
- Digitoxin + Sertraline Hydrochloride— Potential shift in plasma concentrations due to sertraline's tight plasma protein binding, potentially resulting in adve…
Minor (1)
- Digitoxin + Tolcapone— In vitro protein binding studies showed tolcapone did not displace digitoxin from binding sites at therapeutic concentra…